☆ 4.8 Article

Total Synthesis of Human Galanin-Like Peptide through an Aspartic Acid Ligation

ORGANIC LETTERS (2013)

期刊

ORGANIC LETTERS

卷 15, 期 24, 页码 6128-6131

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol402984r

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Chemistry, Organic

资金

University of Colorado Boulder
Butcher Seed Grant

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Reagent

摘要

Human galanin-like peptide (hGALP) is a newly discovered hypothalamic peptide that plays important roles in the regulation of food intake and energy balance. Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of hGALP. The total synthesis of hGALP enhances our ability to study its biology and facilitates the development of more stable analogues.

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