期刊
ORGANIC LETTERS
卷 15, 期 2, 页码 286-289出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303141x
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资金
- Netherlands Organization for Scientific Research (NWO-CW)
- Dutch National Research School Combination Catalysis Controlled by Chemical Design (NRSC-Catalysis)
- China Scholarship Council [2008618001]
An efficient enantioselective synthesis of lactones was developed based on the catalytic asymmetric conjugate addition (ACA) of alkyl Grignard reagents to pyranones. The use of 2H-pyran-2-one for the first time in the ACA with Grignard reagents allows for a variety of further transformations to access highly versatile building blocks such as beta-alkyl substituted aldehydes or beta-bromo-gamma-alkyl substituted alcohols with excellent regio- and stereoselectivity.
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