期刊
ORGANIC LETTERS
卷 16, 期 1, 页码 282-285出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol403282f
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资金
- Natural Science Foundation of China [81102339, 21103234]
- Guangdong Natural Science Foundation [S2011040002429, S2011030003190]
Selaginpulvilins A-D (1-4), four new phenols with an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene skeleton, together with four known selaginellins (5-8) were isolated from Selaginella pulvinata. Their structures were elucidated by spectroscopic analysis and chemical correlation. The structure of 1 was confirmed by single-crystal X-ray diffraction. Compounds 1-8 exhibited remarkable inhibitory activities (IC50 values in the range of 0.11-5.13 mu M) against phosphodiesterase-4 (PDE4), a drug target for the treatment of asthma and chronic obstructive,pulmonary disease.
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