Article
Chemistry, Organic
Chiara M. A. Gangemi, Maria A. Castriciano, Ester D'Agostino, Andrea Romeo, Paola M. Bonaccorsi, Anna Barattucci, Luigi Monsu Scolaro
Summary: A new amphiphilic monosubstituted porphyrin functionalized by a β-D-glucoside terminated oligophenylenethylene has been synthesized and found to self-arrange into nano-aggregates in polar solvents. Emissive rod-like nano-aggregates were obtained in both fluid and solid phases.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Optics
Pallavi Singhal, Vandana Pulhani, Bal Govind Vats
Summary: The present work demonstrates the synthesis and emission properties of a new amphiphilic carbon dot. The study reveals different emission behaviors and the possibility of energy transfer between different excited states. Additionally, the emission properties of the carbon dot vary in different solvents.
JOURNAL OF LUMINESCENCE
(2022)
Article
Polymer Science
Xuan Feng, Nan Yan, Jing Jin, Wei Jiang
Summary: The disassembly process of amphiphilic AB block copolymers in selective solvents was investigated using molecular dynamic simulation. The disassembly is controlled by thermodynamic processes that depend on the instability of the system. Bx can be converted to Ax in A2BxB18-x diblock copolymers by external stimuli, and the instability induced by Bx conversion is a function of x. Increasing x leads to the disassembly of the initial vesicles into various structures. In addition, the Bx conversion rate and the amount of converted polymer chains also affect the disassembly process.
Article
Polymer Science
Brandon R. Clarke, Gregory N. Tew
Summary: We report the synthesis of novel poly(ethylene glycol) and poly(dimethyl siloxane) bottlebrush amphiphilic polymer co-networks, and demonstrate the ability to control their crystallinity and moduli by varying the volume fraction of PEG. These bottlebrush networks represent an unexplored architecture for the field of amphiphilic polymer co-networks.
Article
Multidisciplinary Sciences
Robert Appleby, Daniel Bollschweiler, Dimitri Y. Chirgadze, Luay Joudeh, Luca Pellegrini
Summary: In this study, the researchers investigated the role of RAD51 in homologous recombination. They found that ATP binding to RAD51 promotes its folding into a conformation that allows DNA binding. The presence of a second metal ion at the ATP-binding site explains how RAD51 regulates its interaction with DNA. Loss of the second metal ion upon ATP hydrolysis weakens the stability of RAD51 filament and contributes to its disassembly.
Article
Polymer Science
Kadambari Bairagi, Jiang Tian Liu, Anna Thinphang-nga, Jung Kwon Oh
Summary: Stimuli-responsive degradable amphiphilic block copolymers (SRD-ABPs) have been extensively investigated for the construction of smart nanoassemblies with controlled release of encapsulated molecules. A new approach using conjugated benzoic imine chemistry was developed to achieve dual acidic pH/light responses with a single labile linkage. The synthesized SRD-ABP self-assembled into stable nanoassemblies which degraded upon dual responses to acidic pH and UV/visible light. This work demonstrates the versatility of the new approach for designing advanced nanoassemblies for intracellular drug delivery.
Article
Biochemistry & Molecular Biology
Shihao Su, Qingru Shen, Shuizhong Wang, Guoyong Song
Summary: This study discovered naturally occurring catechyl lignin (C-lignin) in the seed coats of Chinese tallow, which has the highest content of C-lignin. An optimized extraction procedure using ternary deep eutectic solvents (DESs) enabled the complete disassembly of C-lignin and G/S-lignin. Catalytic depolymerization of C-lignin resulted in a simplex catechol product, and derivatizing the black C-lignin led to a whitened C-lignin with uniform laminar structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Yiran Liu, Hanting Wang, Penghui Zhang, Zhixia Wang, Xuan Dong, Menghua Du, Yuanyuan Wang, Lukang Ji
Summary: In this study, an organogelator GCS based on glutamide-cyanostilbene was designed and synthesized. It was found that the gelator could form gel in both polar and non-polar solvents, showing significant circular dichroism signals. By co-assembling with energy acceptors, the energy transfer efficiency in the two-component gels could be tuned by the polarity of the solvents, and white light emitting gels in polar solvents could be obtained by modulating the molar ratio of the donor/acceptor. This work highlights the significance of external modulation such as solvent polarity in energy transfer efficiency in chiral systems.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Duo Wei, Yaozheng Yu, Lingling Ge, Zhifeng Wang, Chong Chen, Rong Guo
Summary: This study utilizes synthesized oligopeptide-perylene diimides (AUPDIs) to generate beta-sheet strands, forming a diversity of morphologies in supramolecular polymers in aqueous media. Complex morphology transitions can be controlled by adjusting the water volume fraction, leading to efficient electronic sensing capabilities.
Article
Chemistry, Physical
Aleksandr Buglakov, Valentina V. Vasilevskaya
Summary: Amphiphilic polymers in mixed solvents can form fibrils and gels through cononsolvency effect. The gelation mechanism is dependent on solvent interactions, and the morphology of the resulting fibrillar gel can be controlled by changing binary solvent composition. This study provides insights into the formation and properties of fibrillar gels, which can be useful for controlling synthetic matrix morphologies in tissue engineering.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Cell Biology
Sahana Shankar, Zi-Ting Hsu, Artur Ezquerra, Chien-Chien Li, Tzu-Lun Huang, Etienne Coyaud, Ricardo Viais, Cedric Grauffel, Brian Raught, Carmay Lim, Jens Luders, Su-Yi Tsai, Kuo-Chiang Hsia
Summary: This study reveals a y-tubulin ring complex (y-TuRC)-dependent pathway that promotes cilia disassembly and prevents cilia formation. It is further demonstrated that Kif2A is recruited to the cilium basal body in a y-TuRC-dependent manner. These findings illustrate the important role of y-TuRC in ciliogenesis.
Article
Chemistry, Multidisciplinary
Seo Yoon Lee, Jinhoon Lee, Yoojung Song, Markus Valtiner, Dong Woog Lee
Summary: This study investigated the pH-dependent molecular interactions between lignin nanofilm and five functionalized self-assembled monolayers using a surface forces apparatus. The results showed that lignin adhered most strongly to the amine-functionalized SAM, indicating that the main interactions were electrostatic and cation-pi interactions. These findings can help advance the potential use of lignin as an eco-friendly biomaterial by providing quantitative results on lignin interactions.
Article
Engineering, Environmental
Junzhen Guo, Liang Chu, Haibin Yang, Zhi Huang, Mu Yang, Ge Wang
Summary: In this study, an amphiphilic Mo/HNT/S nanoreactor was developed by immobilizing MoOx on the internal surface of halloysite nanotubes (HNT) and modifying the external surface with organosilanes. The catalyst exhibited high activity for oxidative desulfurization and showed improved stability over multiple cycles. The amphiphilic nature of the nanoreactor allowed for enhanced dispersion in the oil phase and formation of a concentrated microenvironment for the reactants and reactive oxygen species. This catalytic system eliminates the need for solvent extraction in the desulfurization process, making it a promising candidate for large-scale industrial applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Sapir Rappoport, Varvara Chrysostomou, Martha Kafetzi, Stergios Pispas, Yeshayahu Talmon
Summary: Amphiphilic diblock copolymers and hydrophobically modified random block copolymers can form different structures in a selective solvent. The specific structures depend on the properties of the copolymers, such as the ratio between hydrophilic and hydrophobic segments. By using cryo-TEM and DLS, the structures formed by various copolymers were characterized, including spherical and cylindrical micelles, as well as unilamellar and multilamellar vesicles. This nanostructural characterization has potential applications in the efficient design and utilization of these polymers as carriers for hydrophobic or hydrophilic compounds in biomedicine.
Article
Biochemistry & Molecular Biology
Juan J. Fraire-Zamora, Sebastien Tosi, Jerome Solon, Jordi Casanova
Summary: This study investigates how hormone-driven extracellular matrix remodeling controls tissue shortening and apoptotic cell removal through the transcriptional activity of Yki, leading to organ disassembly during animal development.
Article
Chemistry, Multidisciplinary
Sergi Bujosa, Elisa E. Greciano, Manuel A. Martinez, Luis Sanchez, Bartolome Soberats
Summary: In this study, we reported the liquid-crystalline and luminescent properties of a series of N-annulated perylenes. It was found that the liquid-crystalline properties of these compounds depend on the number and position of hydrogen bonding units and amide linkers in the molecule. Compounds with no hydrogen bonding units in the inner part of the molecule exhibit luminescence vapochromism when exposed to organic solvent vapors.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Manuel A. Martinez, Azahara Doncel-Gimenez, Jesus Cerda, Joaquin Calbo, Rafael Rodriguez, Juan Arago, Jeanne Crassous, Enrique Orti, Luis Sanchez
Summary: The study explores the self-assembling features of two series of N-annulated perylene bisimides, highlighting the significant influence of the distance between the PBI core and the peripheral groups on chiroptical properties and supramolecular polymerization mechanism. The research also shows how attaching the peripheral groups directly to the N-annulated PBI core changes the self-assembling properties and leads to the formation of H-type aggregates with strong aggregation-caused quenching effects. Additionally, a solvent-controlled stereomutation is observed for chiral compounds, resulting in helical supramolecular polymers with different handedness depending on the solvent.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Manuel A. Martinez, Elisa E. Greciano, Jorge Cuellar, Jose M. Valpuesta, Luis Sanchez
Summary: In this study, a highly emissive amphiphilic N-annulated PBI 1 decorated with oligo ethylene glycol (OEG) side chains was synthesized. Compound 1 self-assembles in water to form globular aggregates, demonstrating good solubility and stability in aqueous media. The UV-Vis spectra and solvent denaturation experiments provided insights into the self-assembly process and stability of compound 1 in different solvents.
Article
Chemistry, Multidisciplinary
Jorge S. Valera, Hironari Arima, Cristina Naranjo, Takuho Saito, Natsuki Suda, Rafael Gomez, Shiki Yagai, Luis Sanchez
Summary: The hierarchical self-assembly of scissor-shaped azobenzene dyads leads to the formation of discrete nanotoroids in solution, which further organize into well-defined 2D porous networks on a graphite surface. The steric demand of peripheral aliphatic units controls the stackability of nanotoroids in solution. Additionally, reversible dissociation and reconstruction of nanotoroids can be achieved through UV and visible light photoirradiation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Silvia Collavini, Sebastian F. Volker, Andrea Cabrera-Espinoza, Manuel A. Martinez, Abel De Cozar, Leire San Felices, Luis Sanchez, Juan Luis Delgado
Summary: The straightforward synthesis of three organotin clusters with six triarylamine-based moieties is reported. The optoelectronic properties and gel-forming abilities of the molecules were investigated, and the association abilities were studied using NMR and UV-vis spectroscopy. Comparisons between geometric optimization and X-ray diffraction results provide useful insights into the different gelation behaviors of the compounds.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rafael Rodriguez, Cristina Naranjo, Anil Kumar, Paola Matozzo, Tapan Kumar Das, Qirong Zhu, Nicolas Vanthuyne, Rafael Gomez, Ron Naaman, Luis Sanchez, Jeanne Crassous
Summary: This study reports on the synthesis and self-assembly of 2,15- and 4,13-disubstituted carbo[6]helicenes bearing 3,4,5-tridodecylox-ybenzamide groups. The self-assembly of these helicenes is influenced by the substitution pattern in the helicene core, resulting in different supramolecular structures. The helical supramolecular structures exhibit efficient electron-spin filtering abilities when deposited on conductive surfaces.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Macarena Calero, Lara H. Moleiro, Aline Sayd, Yeray Dorca, Lluis Miquel-Rio, Veronica Paz, Javier Robledo-Montana, Eduardo Enciso, Fernando Accion, Diego Herraez-Aguilar, Thomas Hellweg, Luis Sanchez, Analia Bortolozzi, Juan C. Leza, Borja Garcia-Bueno, Francisco Monroy
Summary: This study presents a colloidal synthesis method for integrating DNA antisense oligonucleotides into lipid nanoparticles, which can be used for the treatment of neuroinflammation-related diseases. The nanoparticles are functionalized to target brain border-associated macrophages and silence specific genes. The results provide a novel approach for gene therapy in neuroinflammation-related diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Cristina Naranjo, Sergio Adalid, Rafael Gomez, Luis Sanchez
Summary: The synthesis and self-assembling features of N-annulated perylenebisimides (N-PBIs) 2-4 are reported and compared with the complex self-assembly of N-PBI 1. Increasing the length of the alkyl spacer leads to the cancellation of differentiation in supramolecular polymerization, except for 2 which forms two different polymorphs. Kinetically trapped monomeric species are observed for N-PBIs 2-4, and their supramolecular polymerization can be accelerated by seed addition. This study sheds light on the intricate process of differentiation in self-assembly.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Rafael Rodriguez, Cristina Naranjo, Anil Kumar, Kais Dhbaibi, Paola Matozzo, Franck Camerel, Nicolas Vanthuyne, Rafael Gomez, Ron Naaman, Luis Sanchez, Jeanne Crassous
Summary: Self-assembling, chiroptical activity, and spin filtering properties of 2,15- and 4,13-disubstituted [6]helicenes decorated with 3,4,5-tris(dodecyloxy)-N-(4-ethynylphenyl)benzamide moieties are reported. The weak non-covalent interaction between the units affects the corresponding circularly polarized luminescence and spin polarization. Self-assembly is weak for these derivatives, and it is explained by the steric effect of the peripheral groups. Additionally, self-assembling features also influence chiral induced spin selectivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Manuel A. Martinez, Daniel Aranda, Enrique Orti, Juan Arago, Luis Sanchez
Summary: The self-assembling features of amphiphilic N-annulated perylene bisimides (N-PBIs) 1-4 in water were investigated experimentally and theoretically. The hydrophilic/hydrophobic ratio, determined by the oligo(ethylene) glycol (OEG) chains in the monomers, plays a significant role in the enthalpy of self-assembly. Molecular dynamic simulations revealed the influence of the initial arrangement of hydrophilic side chains and water-side chain interactions on the enthalpy contribution and overall stability of the aggregated species in water.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Fatima Garcia, Rafael Gomez, Luis Sanchez
Summary: Chiral supramolecular polymers are an important branch within the field of supramolecular polymers, which can generate helical structures and contribute to the research on the origin of homochirality in living organisms as well as the discovery of new functionalities of organic materials. By using chiral monomeric units or external stimuli, chiral supramolecular polymers can be constructed to achieve amplification of asymmetry and break symmetry. Chiral supramolecular polymers have promising applications in various fields.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Fatima Garcia, Rafael Gomez, Luis Sanchez
Summary: Chiral supramolecular polymers are ideal models for generating helical structures, clarifying the origin of homochirality in Nature, or discovering new functionalities of organic materials. This article highlights the commonly used strategies for constructing chiral supramolecular polymers using chiral monomeric units or external stimuli. Examples of selective symmetry transfer and breaking symmetry by applying external stimuli are presented, emphasizing the thermodynamics and kinetics associated with these processes. The specific and promising applications of chiral supramolecular polymers are also introduced with recent relevant examples.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Lucia Lopez-Gandul, Cristina Naranjo, Cecilia Sanchez, Rafael Rodriguez, Rafael Gomez, Jeanne Crassous, Luis Sanchez
Summary: This study described the synthesis of two pairs of enantiomeric cyano-luminogens and investigated their supramolecular polymerization under kinetic and thermodynamic control. The compounds exhibited different aggregation states and chiroptical properties, and the chiroptical features strongly depended on the nature of the central aromatic unit.
Article
Chemistry, Organic
Elisa E. Greciano, Manuel A. Martinez, Silvia Alsina, Andres Laguna, Luis Sanchez
Summary: The chiroptical features of N-annulated perylenetetracarboxamides 1-4, their self-assembling properties, and supramolecular polymerization mechanism have been investigated. The study demonstrates that compounds 1-3 can efficiently transfer asymmetry, while compound 4 cannot.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Cristina Naranjo, Yeray Dorca, Goutam Ghosh, Rafael Gomez, Gustavo Fernandez, Luis Sanchez
Summary: The kinetically controlled amplification of asymmetry experienced in the co-assembly of chiral tribiphenylaminetricarboxamides (S)-1 and (R)-1 is investigated, with the formation of metastable monomeric species through intramolecular H-bonds retarding the efficient amplification of asymmetry due to a chain-capper effect.
CHEMICAL COMMUNICATIONS
(2021)
