期刊
ORGANIC LETTERS
卷 15, 期 20, 页码 5254-5257出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol402473m
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资金
- National Natural Science Foundation of China [21102111, 21102110]
- Fundamental Research Funds of the Central Universities
A metal-free oxidative spirocyclization of hydroxymethylacrylamide with 1,3-dicarbonyl compounds is described. The reaction proceeds through tandem dual C-H functionalization and intramolecular dehydration, in which two new C-C bonds and one C-O bond were formed. This method affords a novel and straightforward access to various spirooxindoles under mild conditions.
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