Article
Materials Science, Composites
Wei Wang, Ting Zhang, Hangsan Fang, Zhixing Zhang, Zujun Peng, Zhijian Wang, Jun Ai, Fei Zhang
Summary: In this work, a facile technology based on the structural and dimensional engineering of carbon nanotube (CNT) conducting networks was proposed to fabricate a flexible and stretchable strain sensor with tunable sensitivity and superior linearity. The strain sensors based on the CNT/polydimethylsiloxane (CNT/PDMS) composites exhibited tunable sensitivities and excellent linearity and repeatability.
COMPOSITES COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Kohei Umedera, Atsushi Yoshimori, Hengwei Chen, Hiroyuki Kouji, Hiroyuki Nakamura, Juergen Bajorath
Summary: Mimicking bioactive conformations of peptide segments involved in protein-protein interaction interfaces is a promising strategy for designing PPI inhibitors. DeepCubist is a molecular generator based on 3D scaffolds that can be used to design peptidomimetics for pharmaceutical targets engaging in PPIs.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
(2023)
Article
Optics
Kezhen Jin, Zeren LI, Pengyu Nan, Guoguo Xin, Kok-Sing Lim, Harith Ahmad, Hangzhou Yang
Summary: A flexible haptic sensor based on dual fiber Bragg gratings is proposed for the detection of 3D forces. The sensor can discriminate normal and tangential force angles and magnitudes by embedding the FBGs in a flexible silicone cylinder. The results demonstrate the sensor's capability to detect the angle and magnitude of 3D forces.
Article
Chemistry, Multidisciplinary
Yashoda Krishna Sunkari, Vijay Kumar Siripuram, Marc Flajolet
Summary: The DNA-encoded library (DEL) technology is an innovative drug-discovery tool that combines combinatorial chemistry and DNA barcoding to achieve unprecedented screening power. With the introduction of new DNA-compatible reactions, the chemical diversity and space of DELs will continue to expand. This research demonstrates the use of DOS in the synthesis of on-DNA peptidomimetics and the development of on-DNA alpha, beta-unsaturated ketones and chalcone-based molecules through Wittig olefination. Furthermore, the successful application of DOS with electron-deficient peptidomimetics led to the creation of heterocyclic cores containing on-DNA peptidomimetics.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Chuan Cai, He Gong, Weiping Li, Feng Gao, Qiushi Jiang, Zhiqiang Cheng, Zhaolian Han, Shijun Li
Summary: A high-performance flexible pressure sensor composed of Fe3O4/carbon nanofibers was fabricated using three-dimensional electrospinning and heat treatment methods. The sensor demonstrates a wide working range, high sensitivity, rapid response time, good stability, and excellent flexibility, making it suitable for real-time healthcare monitoring applications.
Article
Physics, Applied
Shasha Li, Yuning Li, Jingye Sun, Fang Su, Weijie Yin, Mingqiang Zhu, Tao Deng
Summary: This paper proposes a self-powered vibration sensing element based on rolled-up single-layer graphene, breaking the inversion symmetry of the single-layer graphene to achieve piezoelectricity. The device is sensitive to mechanical vibrations with different frequencies and can be used for sensing, actuating, and energy harvesting applications.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Zhendong Guo, Jing Wang, Wan-Jian Yin
Summary: It is discovered that the lattice softness of lead-halide perovskites (LHPs) mainly depends on the steric size and valency of their compositional elements, while previously assumed principal causes do not play the primary role. Through first-principles calculations, the direct correlations between ionic size/valency, lattice softness, structure disorder, and carrier dynamics are comprehensively investigated.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Duorui Wang, Xiangming Li, Hongmiao Tian, Xiaoliang Chen, Bangbang Nie, Yongsong Luo, Jinyou Shao
Summary: A new type of flexible strain sensor was fabricated by embedding 3D annular cracks in the elastomer, showing high sensitivity and detection resolution. Optimized fiber weaving structure improved the device performance and stability, enhancing the sensing capability and mechanical robustness.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Multidisciplinary
Chao Wang, Wenzhe Han, Bin Xu, Jianhua Rong
Summary: This paper proposes an efficient structural topology optimization approach to achieve the blueprint and model designs with uniform dimensional shrinkage. An appropriate two-projected-field scheme is established to simulate the designs, and an effective quantitative framework is constructed to predict the shrinkage rules. The proposed approach enables engineers to achieve predictable dimensional shrinkage in an optimization way.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Engineering, Geological
Shuxi Zhao, Siming He, Xinpo Li, Yu Deng, Yang Liu, Shuaixing Yan, Xiuqiang Bai, Yanfang Xie
Summary: This study used the three-dimensional material point method to simulate the Xinmo village rock avalanche disaster, providing better understanding through fragmentation and entrainment effects. The simulated results matched the observed results fairly well, offering valuable insights for physically based risk assessments.
ENGINEERING GEOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yutian Li, Xuhong Miao, Jonathan Y. Chen, Gaoming Jiang, Qing Liu
Summary: A knitted strain sensor was designed and fabricated for human motion detection applications. A new method using a three-dimensional curved surface was proposed to evaluate the sensing performance, showing a sensing range twice that of the traditional two-dimensional method. This research suggests that the three-dimensional testing method could effectively evaluate the sensing performance of fabric strain sensors.
MATERIALS & DESIGN
(2021)
Article
Nanoscience & Nanotechnology
Chongsheng Yu, Tai Sun, Bowei Zhao, Mengqin Zhang, Mingxin Gu, Yuanchang Lin, Guotian He, Zongyong Chen, Tingmao Liao, Haofeng Ran, Jialu Li, Shi Luo, Dapeng Wei
Summary: This study focuses on a high-sensitive flexible strain sensor, which combines the design of graphene-SiO2 balls enhanced three-dimensional graphene foam electrode structure with the flexible material polydimethylsiloxane (PDMS). The sensor shows excellent performance and can be used in various wearable applications.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2022)
Article
Chemistry, Multidisciplinary
Kohei Umedera, Taiki Morita, Atsushi Yoshimori, Kentaro Yamada, Akira Katoh, Hiroyuki Kouji, Hiroyuki Nakamura
Summary: A novel sp(3) carbon-rich tricyclic 3D scaffold-based peptide mimetic compound library was constructed to target protein-protein interactions. The designed compounds exhibited potential antiproliferative, anti-cancer, and antiviral activities, with compound 21a showing the strongest inhibitory activity against HIF-1 transcriptional activity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Mechanics
M. M. Mirsayar
Summary: The concept of effective critical distances is introduced to construct a novel mixed-mode I/II/III brittle fracture criterion (ECD-SN criterion), which shows superior estimates compared to traditional criteria when predicting experimental data for mixed-mode fracture toughness and fracture angles.
ENGINEERING FRACTURE MECHANICS
(2021)
Review
Multidisciplinary Sciences
Tingting Yang, Xin Jiang, Yuehua Huang, Qiong Tian, Li Zhang, Zhaohe Dai, Hongwei Zhu
Summary: This review summarizes the latest developments in mechanical sensors based on two-dimensional (2D) materials from the perspective of function-oriented applications. The review introduces typical mechanical sensing mechanisms and attempts to establish a correspondence between typical structure designs and the performance/multi-functions of the devices. Promising areas for potential applications are discussed, and perspectives on current challenges and future opportunities are presented.
Article
Chemistry, Medicinal
Yuta Sato, Naoko Oyobe, Takao Ogawa, Sayo Suzuki, Hiroshi Aoyama, Tomonori Nakamura, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
Summary: The absolute structure of an indole alkaloid, (+)-cinchonaminone, was determined through total synthesis of both (+)-cinchonaminone and its enantiomer. The study mainly focused on enantioselective synthesis of a chiral cis-3,4-disubstituted piperidine and evaluated their monoamine oxidase inhibitory activities. Additionally, structurally simplified derivatives without chiral centers were synthesized, with two of them showing stronger MAO inhibitory activities than (+)-cinchonaminone.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Analytical
Jun Haginaka, Taku Yamashita, Hirofumi Tsujino, Mitsuhiro Arisawa
Summary: Chiral binding sites were located on cAGP, consisting of residues contributing to electrostatic or hydrogen bonding interactions for chiral recognition. Different compounds enantiomers interacted with cAGP at slightly different positions and modes, involving hydrophobic interactions and hydrogen bonding interactions for chiral recognition.
Article
Chemistry, Multidisciplinary
Yuta Sato, Tsuyoshi Matsuzaki, Tsunayoshi Takehara, Makoto Sako, Takeyuki Suzuki, Mitsuhiro Arisawa
Summary: Multitasking single-catalyst systems are crucial for eco-compatible chemistry, and we have developed a rhodium-catalyzed system that can convert 1-(allyloxy)-2-(cyclopropylmethyl)benzene derivatives to 2-ethyl-3-isopropylbenzofurans via double isomerization/cycloisomerization/aromatization.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Ryousuke Ohta, Yasunori Shio, Toshiki Akiyama, Makito Yamada, Shuhei Shimoda, Kazuo Harada, Makoto Sako, Jun-ya Hasegawa, Mitsuhiro Arisawa
Summary: In this study, a carbon(sp(2))-carbon(sp(3)) bond-forming cross-coupling reaction was achieved using a nano-size nickel catalyst supported on sulfur-modified gold (SANi). The reaction showed good yields and low leaching of nickel from the catalyst. The SANi catalyst could also be recycled multiple times without significant loss of activity.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Makito Yamada, Yu Hirose, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Sirimangkalakitti Natchanun, Naoyuki Takahashi, Yuuta Ohki, Makoto Sako, Kenichi Murai, Kazuo Harada, Masayoshi Arai, Sayo Suzuki, Tomonori Nakamura, Junichi Haruta, Mitsuhiro Arisawa
Summary: This study reports the screening of N-arylated heliamine derivatives as MAO-B selective inhibitors using microwave-assisted synthesis, and identifies 4h, 4i, and 4j as potent inhibitors of MAO-B.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Shohei Yoshioka, Tsunayoshi Takehara, Takeyuki Suzuki, Mitsuhiro Arisawa
Summary: This paper presents the first report on the intramolecular [2+2] cycloaddition of vinylsilane. Previous studies have focused on controlling regioselectivity in the [2+2] cycloaddition of allenes by changing the substrate, but no research has attempted to achieve this solely by altering the reaction conditions. In this study, we successfully controlled the intramolecular [2+2] cycloaddition at proximal and distal positions of allenes by modifying the reaction conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Mizushi Yanagihara, Kanae Nakahara, Naoki Kishimoto, Towa Abe, Satoshi Miura, Shogo Misumi, Makoto Sako, Mitsuhiro Arisawa, Kenichi Murai
Summary: The first total synthesis of marine sesterterpenoid ansellone G and phorbadione was achieved, and their HIV latency-reversing activity was evaluated.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Keigo Saito, Hiroshi Aoyama, Makoto Sako, Kenichi Murai, Mitsuhiro Arisaw
Summary: A double ring expansion strategy for constructing fused 3-benzazepines was developed. The strategy involved oxidative ring expansion of spiroamine compounds and subsequent ring expansion of ketiminium ion intermediates. Moreover, the synthesis of Dolby-Weinreb enamine, a key intermediate for harringtonine alkaloids and cephalotaxines, was achieved in only two steps using this method.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Natchanun Sirimangkalakitti, Kazuo Harada, Makito Yamada, Masayoshi Arai, Mitsuhiro Arisawa
Summary: The aim of this work was to produce new compounds through a one-step reaction of substances present in marine sponge extracts. A new tetracyclic bromopyrrole-imidazole derivative was discovered, along with two previously unreported compounds. The results demonstrate the efficacy of direct chemical diversification in the discovery of new compounds.
Article
Chemistry, Inorganic & Nuclear
Ray Miyazaki, Kenji Iida, Shohei Ohno, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Mitsuhiro Arisawa, Jun-ya Hasegawa
Summary: 2,3-disubstituted benzofurans with potential for pharmaceutical applications are effectively synthesized by Ni complexes via intramolecular C-O bond activation. The reaction pathway of the catalytic cycle has been studied using density functional theory (DFT) calculations. It was found that the rate-determining step is the reductive elimination of the product. A key finding is that coordination to an alkynyl group of another substrate occurs simultaneously with elimination, enhancing the thermodynamic stability of the product and determining the reaction pathway of the catalytic cycle. The reductive elimination assisted by solvent molecules or free ligand results in an endergonic reaction. This result can be considered as a self-cocatalytic effect of the substrate and adds a new perspective to the design of catalytic reaction systems with effective catalytic cycles.
Article
Chemistry, Multidisciplinary
Mizushi Yanagihara, Naoki Kishimoto, Kanae Nakahara, Towa Abe, Satoshi Miura, Bangzhong Lin, Megumi Fumimoto, Junichi Haruta, Shogo Misumi, Mitsuhiro Arisawa, Kenichi Murai
Summary: Structurally simplified analogues of ansellone A were synthesized by replacing the decalin skeleton with a lipophilic chain, and their HIV latency-reversing activities were evaluated. Two analogues with ether and alkenyl side chains showed comparable activities to ansellone A. The simplified compounds were easily synthesized using Prins cyclisation chemistry.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Yuta Chikashige, Tsunayoshi Takehara, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Kenichi Murai, Mitsuhiro Arisawa, Makoto Sako
Summary: A novel chiral borinic acid (CBA) with a binaphthyl skeleton was successfully designed and synthesized. The synthesis of CBA was achieved starting from optically pure 1,1'-bi-2-naphthol and resulted in a 72% yield in four steps. The asymmetric catalytic activity of CBA was investigated in the desymmetrization of meso-1,2-diol.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Shohei Yoshioka, Masaharu Takatsuki, Tsunayoshi Takehara, Takeyuki Suzuki, Mitsuhiro Arisawa
Summary: Sulfonylindoles were synthesized via migratory cycloisomerization using an allene N-tosyl-o-allenylaniline. 3-tosyl indoles or 4-tosyl indoles were selectively produced using a Pd catalyst or a Au catalyst, respectively.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ryosuke Ohta, Yasunori Shio, Toshiki Akiyama, Makito Yamada, Kazuo Harada, Mitsuhiro Arisawa
Summary: Ligand-free reductive coupling of aldehydes with 1,3-dienes was achieved using the nickel nanoparticle catalyst SANi. Minimal leakage of nickel species into the reaction solution was observed. SANi can be reused and the reaction is environmentally friendly.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Shohei Ohno, Mitsuhiro Arisawa
Summary: Cyclization reactions between multiple bonds and heteroatom-substituted olefins have been a fascinating area of study, allowing the discovery of new reactions and the construction of carbo- and heterocycles. Recent reports have shed light on the reactions in this area, providing valuable insights into their reaction mechanisms and synthetic applications.
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
(2021)
