4.8 Article

Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation

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ORGANIC LETTERS
卷 15, 期 5, 页码 1036-1039

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AMER CHEMICAL SOC
DOI: 10.1021/ol303483t

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资金

  1. National Institutes of Health [GM58832]
  2. China Scholarship Council
  3. National Key S&T Research Foundation of China [2010CB126105]
  4. Scholarship Award for Excellent Doctoral Student
  5. Ministry of Education
  6. Division Of Chemistry
  7. Direct For Mathematical & Physical Scien [0956784] Funding Source: National Science Foundation

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A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.

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