期刊
ORGANIC LETTERS
卷 15, 期 3, 页码 646-649出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303465c
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资金
- National Science Foundation [CHE-1110599]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1110599] Funding Source: National Science Foundation
An iridium-catalyzed asymmetric hydrogenation of 1,1-diarylkenes is described. Employing a novel, modular phosphoramidite ligand, PhosPrOx, in this transformation affords biologically relevant 1,1-diarylmethine products in good enantiomeric ratios (96.5:3.5 to 71:29). We propose that a meta-directing group, 3,5-dimethoxyphenyl, is responsible for the observed enantioselection, the highest reported, to date, for iridium-catalyzed hydrogenation of 1,1-diarylalkenes lacking ortho-directing groups.
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