4.8 Article

I2/TBHP-Catalyzed Chemoselective Amination of Indoles

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ORGANIC LETTERS
卷 15, 期 20, 页码 5226-5229

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AMER CHEMICAL SOC
DOI: 10.1021/ol4023936

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资金

  1. Natural Science Foundation of China [21172162]
  2. Young National Natural Science Foundation of China [21202111]
  3. Young Natural Science Foundation of Jiangsu Province [BK2012174]
  4. PAPD
  5. Soochow University

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A novel I-2/TBHP-mediated direct oxidative diamination reaction of indoles with anilines was developed. The reaction proceeded smoothly under aqueous and open air reaction conditions. This protocol provides a practical synthetic method for the synthesis of Tryptanthrin and the construction of N-C3 linked pyrrolidinoindolines which is the core structure of Psychotrimine.

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