☆ 4.8 Article

Concise Synthesis of Reduced Propionates by Stereoselective Reductions Combined with the Kobayashi Reaction

ORGANIC LETTERS (2013)

期刊

ORGANIC LETTERS

卷 15, 期 12, 页码 3170-3173

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol401406m

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Chemistry, Organic

资金

Waseda University
Ministry of Education, Culture, Sports, Science and Technology (MEXT) [22350045]
MEXT, Japan
Grants-in-Aid for Scientific Research [22350045, 25620088] Funding Source: KAKEN

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摘要

A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukalyama aldol reaction and regio- and stereoselective reduction reactions. All Isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

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