☆ 4.8 Article

N-Heterocyclic Carbene Catalyzed Oxidative Coupling of Aldehydes with Carbodiimides under Aerobic Conditions: Efficient Synthesis of N-Acylureas

ORGANIC LETTERS (2013)

期刊

ORGANIC LETTERS

卷 15, 期 9, 页码 2088-2091

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol400672c

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Chemistry, Organic

资金

Japan Society for the Promotion of Science [24750037, 24350022]
Grants-in-Aid for Scientific Research [24750037, 25620028] Funding Source: KAKEN

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摘要

The oxidative coupling reaction of aldehydes with N,N-disubstituted carbodiimides catalyzed by N-heterocyclic carbenes under aerobic conditions has been achieved. This reaction gives the corresponding N-acylurea derivatives in good to high yields. Various kinds of aldehydes including aliphatic ones and carbodiimides are applicable to this reaction.

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