4.8 Article

Synthesis of Solid 2-Pyridylzinc Reagents and Their Application in Negishi Reactions

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ORGANIC LETTERS
卷 15, 期 22, 页码 5754-5757

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AMER CHEMICAL SOC
DOI: 10.1021/ol402798z

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资金

  1. National Institutes of Health [GM46059, 3-R01-GM046059-20S]
  2. National Science Foundation [CHE-9808061, 1122374]
  3. European Research Council under the European Community [227763]

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In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions.

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