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Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives

ORGANIC LETTERS (2012)

期刊

ORGANIC LETTERS

卷 14, 期 16, 页码 4074-4077

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol3016989

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类别

Chemistry, Organic

资金

National Institutes of Health [RO1GM3540, R01CA140296]

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Reagent

摘要

A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity.

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