期刊
ORGANIC LETTERS
卷 14, 期 24, 页码 6362-6365出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303168y
关键词
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资金
- NSFC [20802082, 30830115, 81102483]
- CAS [KSCX2-EW-Q-10, KSCX1-YW-R-24]
- 973 programs [2009CB522300, 2009CB940900]
- Natural Science Foundation of Yunnan Province [2012FB178]
- project of recruited top talent of sciences and technology of Yunnan Province [2009C1120]
- Key Scientific and Technological Projects of China [2009ZX09501-029, 2012ZX10001-006]
A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C-9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 mu g/mL, respectively.
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