期刊
ORGANIC LETTERS
卷 14, 期 19, 页码 5050-5053出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol3022758
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资金
- University of Wisconsin-Madison School of Pharmacy
- Graduate School at the University of Wisconsin
- UW College of Agriculture and Life Sciences
- NIH, NIGMS [R01 GM092009]
- NIH [P41RR02301, P41GM66326, RR02781, RR08438]
- University of Wisconsin
- NSF [DMB-8415048, OIA-9977486, BIR-9214394]
- USDA
Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway.
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