4.8 Article

Palladium-Catalyzed Intermolecular C3 Alkenylation of Indoles Using Oxygen as the Oxidant

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ORGANIC LETTERS
卷 14, 期 23, 页码 5920-5923

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AMER CHEMICAL SOC
DOI: 10.1021/ol302840b

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资金

  1. National Natural Science Foundation of China [NSFC-20872183, 20972126]
  2. Program for New Century Excellent Talents in University of the Ministry of Education China [NCET-10-0937]
  3. Education Department of Shaanxi Provincial Government [09JK776]

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A general and efficient palladium-catalyzed intermolecular direct C3 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is of complete regio- and stereoselectivity. All products are E-isomers at the C3-position, and no Z-isomers or 2-substituted product can be detected.

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