期刊
ORGANIC LETTERS
卷 14, 期 15, 页码 3978-3981出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol301750b
关键词
-
资金
- National Natural Science Foundation of China [21125210, 21121062]
- Chinese Academy of Science
- Major State Basic Research Development Program [2011CB808700]
3-Acylindoles undergo nucleophilic-type reactions with Grignard reagents to efficiently afford either cis- or trans-substituted indolines, depending on the different quenching procedures. The enolate intermediate could be trapped by aryl acyl chlorides to provide indolines bearing a quaternary carbon center with high stereoselectivity. In contrast, the use of benzyl bromide as an electrophile results in the fragmentation of the indole ring. The indoline products could be easily transformed Into indoles through oxidation with DDQ in a one-pot manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据