期刊
ORGANIC LETTERS
卷 14, 期 5, 页码 1258-1261出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol300108z
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资金
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2011-0015931, 2011-0030635]
- Howard Hughes Medical Institute
- National Research Foundation of Korea [2011-0015931] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na+/K+ ATPase inhibitor (IC50 = 16.6 mu g/mL).
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