期刊
ORGANIC LETTERS
卷 14, 期 4, 页码 1138-1141出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol3000712
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-
资金
- National institute of General Medical Sciences of the National Institutes of Health [GM096403]
The development of peptide-based oxidation catalysts that use a transiently generated dioxirane as the chemically active species is reported. The active catalyst is a chiral trifluoromethyl ketone (Tfk) with a pendant carboxylic acid that can be readily incorporated into a peptide. These peptides were capable of epoxidizing alkenes in high yield (up to 89%) and enantiomeric ratios (er) ranging from 69.0:31.0 to 91.0:9.0, depending on the alkene substitution pattern.
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