Article
Chemistry, Organic
Mayur I. Morja, Prakashsingh M. Chauhan, Kishor H. Chikhalia
Summary: This study introduces a novel strategy for Iron(II)-catalyzed alkynylation of thiohydantoins with terminal alkyne, showcasing its tolerance to various functional group transformations. The optimized method provides a unified approach to access alkynylated thiohydantoins in moderate to higher yields via C(sp(3))-C(sp) bond formation.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Chunqi Jia, Nini Wu, Gang Li, Xiuling Cui
Summary: In this study, a new method for the oxidative meta-dehydrogenative allylation of arenes with alkenes has been successfully developed using Ru(PPh3)3Cl2 as a catalyst and DTBP as an oxidant. The results demonstrate that this method provides an efficient and practical strategy for the preparation of versatile meta-allylated arenes.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nian Xu, Maoping Pu, Han Yu, Gaofei Yang, Xiaohua Liu, Xiaoming Feng
Summary: This study achieved the direct alpha-alkylation of acyclic carbonyls with nonactivated hydrocarbons using iron-based catalysts, resulting in highly selective products. The use of a chiral iron complex and oxidants allowed for the high enantioselectivity (up to 99% ee) with good compatibility in yields (up to 88%).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Muhammad Siddique Ahmad, Zahid Shafiq, Kamel Meguellati
Summary: In this study, a mild and selective cross dehydrogenative coupling (CDC) method mediated by Cu(I) was developed. Commercial low-cost unactivated alkenes and tetrahydrofuran derivatives were used as the source of ether and solvent, resulting in the synthesis of alpha-functionalized cyclic ethers. The method exhibited excellent selectivity and yield and can be applied to a wide range of aromatic alkenes, heteroaromatic alkenes, and cyclic ethers, providing valuable insights for the design of versatile alkenyl cyclic ethers.
Article
Chemistry, Physical
Anna, Zhaohang Chen, Hongwei Qiao, Juanhong Gao, Mengyao Zhu, Chao Li
Summary: A series of xanthone derivatives were synthesized by rhodium-catalyzed cycloaddition and sequential oxidation, demonstrating wide applicability. The derivatives showed excellent yields and different substituent electron effects, highlighting the potential of the proposed approach. The successful one-pot synthesis from 1ethynyl-2-phenoxybenzene further emphasized the attractiveness of the current method for xanthone synthesis.
CATALYSIS COMMUNICATIONS
(2021)
Review
Chemistry, Organic
C. M. A. Afsina, Thaipparambil Aneeja, Mohan Neetha, Gopinathan Anilkumar
Summary: Copper-catalyzed organic reactions have attracted widespread attention due to the abundance and affordability of copper, as well as its low toxicity, eco-friendliness, sustainable nature, and versatility as a catalyst. These reactions are primarily used for the synthesis of biologically important nitrogen heterocycles, amines, amides, imines, and alkynes.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kashanna Jajula, Rathod Aravind Kumar, Ravada Kishore, Prakash Raj Thommandru, Ravula Shrikanth, Sirasani Satyanarayana, Pilli V. V. N. Kishore
Summary: The silver(i)-catalyzed dehydrogenative cross-coupling reaction between 2-aroylbenzofurans and phosphites to produce 2-aroyl-3-phosphonylbenzofurans is reported. This reaction exhibits moderate to good yields and high regioselectivity.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Wei Wei, Xiaodan Zhao
Summary: The carbon-carbon bond-forming cross-dehydrogenative coupling reaction using organoselenium catalysis involving a high-valent para-methoxyphenyl selenium species has been developed. This method enables the synthesis of alpha,alpha-disubstituted alpha-amino acid derivatives with excellent regioselectivities through vinyl or allylic C-H functionalization. The generality of this method has been demonstrated by the cross-coupling of an alkene with an oxindole and the direct functionalization of electron-rich arenes with azlactones.
Article
Chemistry, Multidisciplinary
Gyumin Kang, Sunkyu Han
Summary: In this study, we successfully synthesized dimeric high-oxidation-state securinega alkaloid Flueggeacosine B via two synthetic routes. The second-generation synthesis was more streamlined and a new reaction was developed to provide a direct pathway for the synthesis of compounds with a conjugated dicarbonyl moiety.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Yingxiang Hua, Yanchao Lin, Wenyi Chen, Liyi Ye, Yingwu Yin, Yuxing Gao, Song Tu
Summary: A copper-catalyzed oxidative cross-dehydrogenative coupling (CDC) strategy for the synthesis of various phosphinate esters was proposed. The reaction proceeded under mild conditions and exhibited good substrate tolerance, providing the desired compounds in moderate to excellent yields.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Christopher Cremer, Monalisa Goswami, Christian K. Rank, Bas de Bruin, Frederic W. Patureau
Summary: This study reports the Te-II/Te-III-catalyzed dehydrogenative C-H phenothiazination of challenging phenols with electron-withdrawing substituents under mild aerobic conditions, achieving high yields. The unexpected Te-II/Te-III radical catalytic properties were characterized through cyclic voltammetry, EPR spectroscopy, kinetic experiments, and DFT calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Xiaolan Li, Haiqing Luo, Ruixin Song, Yuting Zhang, Xian Gong, Hu Cai, Xuzhong Luo
Summary: The developed methodology demonstrates an efficient Rh(III)-catalyzed oxidative C-H/C-H cross-coupling reaction between acyclic enamides and heteroarenes. This reaction offers advantages of excellent regio- and stereoselectivity, good compatibility with various functional groups, and a broad range of substrates. Mechanistically, Rh(III)-catalyzed β-C(sp(2))-H activation of acyclic enamides is proposed as the crucial step.
Article
Chemistry, Organic
Yumi Kang, Soomin Jeon, Hayoung Kim, Jonghyeok Han, Garam Choi, Eun-Kyu Sun, Rameshwar Prasad Pandit, Tae-Hyun Kim
Summary: Silver-catalyzed cross-dehydrogenative coupling of benzoxazin-2-ones with resorcinol was achieved using inexpensive ammonium persulfate as an oxidant. This method provides a direct C3-arylation of benzoxazin-2-ones at ambient condition. The reaction mechanism involves a radical pathway.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Organic
Akanksha Singh Baghel, Anjali Aghi, Amit Kumar
Summary: The regioselective ortho-alkenylation of primary benzamides with activated olefins using a Ru(II) catalyst has been achieved, allowing the controlled introduction of olefin motifs at the ortho-position of benzamides. The success of this strategy relies on fine-tuning reaction conditions and involves a base-assisted internal electrophilic-type substitution step in the reaction mechanism.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Haifeng Chen, Chen Zhu, Huifeng Yue, Magnus Rueping
Summary: An efficient cobalt-catalyzed carbon-germanium bond formation method has been developed, providing access to a wide range of functionalized germane-containing compounds. This method shows a broad scope and good tolerance toward various functional groups, and is conducted under mild reaction conditions. Mechanistic studies shed light on the unexpected reaction pathway and sequential activation of different electrophiles.
Article
Gastroenterology & Hepatology
Lihong Mao, Chaoqun Li, Xiaoyu Wang, Mingyu Sun, Yifan Li, Zihan Yu, Binxin Cui, Gaoyue Guo, Wanting Yang, Yangyang Hui, Xiaofei Fan, Jie Zhang, Kui Jiang, Chao Sun
Summary: This study found that in decompensated cirrhosis, low subcutaneous adipose tissue index (SATI) and concurrent total adipose tissue index (TATI) were associated with an increased risk of frailty.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Fisheries
Min Cao, Qi Li, Xiantong Liu, Qiang Fu, Chao Li
Summary: Sebastes schlegelii is a fish species with high economic value, but the outbreak of diseases in its aquaculture industry has caused significant economic losses. Study of the fish immune system, particularly the immunoglobulin genes, can provide insights into the immune response to pathogens and contribute to the development of prevention and control methods. This study successfully identified and cloned the immunoglobulin heavy chain genes (sIgM, mIgM, sIgT, and mIgT) of S. schlegelii, revealing their high conservation during evolution.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xiaoyan Zhang, Haohui Yu, Ningning Wang, Chao Li
Summary: Evidence suggests that lncRNAs are involved in various immune responses in vertebrates. In the snakehead fish, immune-related lncRNAs play crucial roles in regulating immune responses against Nocardia seriolae infection. This study analyzed the transcription landscapes of lncRNAs and mRNAs in snakehead, revealing potential functions of lncRNAs in modulating mRNA expression levels and regulating downstream immune signaling pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xin Cai, Chengbin Gao, Alan J. Lymbery, Nicola J. Armstrong, Le Ma, Chao Li
Summary: Recently, the Gram-negative pathogenic bacterium Vibrio anguillarum has become a major obstacle to the turbot aquaculture industry due to its global distribution, wide host range, and potential devastating impacts. This study conducted comprehensive analyses of whole-transcriptome sequencing in turbot liver infected by V. anguillarum and found differential expression of circRNAs, miRNAs, and mRNAs. Interaction pairs between miRNA-circRNA and miRNA-mRNA were predicted and circRNA-related ceRNA regulatory networks were constructed. The study identified novel target genes for disease prevention and control in turbot.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Yiping Liu, Min Cao, Xu Yan, Xin Cai, Yuqing Li, Chao Li, Ting Xue
Summary: Cell-to-cell communication through gap junction channels is essential for coordinating cellular functions in multicellular tissues. This study identified 48 members of the gap junction protein family in Sebastes schlegelii, classifying them into connexin and pannexin types. The connexins were further divided into five subfamilies. The study also revealed the protein structure and interactions of GJs, and showed that GJ proteins were highly expressed in intestinal tissues and regulated after bacterial infection. The findings provide valuable insights for further understanding the function of GJ proteins in S. schlegelii.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Mingxin Liu, Zewen Wu, Xianghua Kong, Xu Zhang, Lida Tan, Hong Guo, Chao-Jun Li
Summary: The generation of BTX compounds from non-petroleum feedstocks is important for chemists in terms of sustainability. A novel synthesis of toluene catalyzed by GaN semiconductor nanowire arrays is reported, which can facilitate the generation of toluene from methane and methanol under both photo-irradiation and thermal conditions. Detailed computational studies revealed different mechanisms for photo- and thermal toluene synthesis.
Article
Chemistry, Multidisciplinary
Chao-Jun Li
Summary: Modern synthetic chemistry relies heavily on stoichiometric organometallic reagents to react with various electrophiles. However, the dependence on stoichiometric quantities of metals and organic halides leads to metal halide wastes and concerns on metal sustainability. Inspired by classical reduction reactions, our lab has developed a general strategy called HOME-Chemistry that directly uses abundant alcohols/aldehydes and ketones as feedstocks, releasing harmless water and nitrogen gas. This article provides a brief summary of this chemistry.
PURE AND APPLIED CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jianjin Yu, Renqin Zhan, Chao-Jun Li, Huiying Zeng
Summary: In this study, iodomethane was used as a C1 organocatalyst for the aerobic ortho-selective trifluoromethylation of pyridines without a transition metal. Trifluoroacetic acid was employed as an affordable and readily available trifluoromethyl source. The reaction showed good functional group compatibility and could selectively trifluoromethylate pyridine-containing drug molecules for late-stage functionalizations.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Juan D. D. Lasso, Durbis J. J. Castillo-Pazos, Malcolm Sim, Joaquin Barroso-Flores, Chao-Jun Li
Summary: Despite being well-known for their photochemical properties and industrial value, the use of nitroarenes as a productive photochemical handle in organic synthesis has been relatively unexplored. In this study, we report the design and application of a sulfinate-nitroarene electron donor-acceptor (EDA) complex, which enabled the first light mediated catalyst-free synthesis of N-hydroxy-sulfonamides. The EDA complex was characterized spectroscopically and studied using DFT and TD-DFT calculations. A total of 32 examples with electron withdrawing and electron donating groups were synthesized under oxygen- and water-tolerant conditions.
Article
Computer Science, Information Systems
Jian Cheng, Quanyuan Feng, Chao Li, Wenxiu Yang
Summary: In this paper, a new run-time monitoring technique is proposed to detect hardware Trojans (HT) on working field-programmable gate array (FPGA), which can enhance the hardware security of IoT devices. The technique places multiple temperature sensors on FPGA and collects their values at each time interval. A predictive model is constructed to estimate the real-time distribution of sensor frequency. If the difference between the predicted value and the real one exceeds a dynamically updated threshold, an HT activation is reported. The experiment results demonstrate that the technique achieves high detection accuracy (>= 98%), low false negative ratio (<= 1.5%), and zero false positive ratio under various FPGA HT benchmarks.
Article
Endocrinology & Metabolism
Peng Wang, Haifeng Sun, Gulisudumu Maitiabula, Li Zhang, Jianbo Yang, Yupeng Zhang, Xuejin Gao, Jieshou Li, Bin Xue, Chao-Jun Li, Xinying Wang
Summary: Total parenteral nutrition (TPN) can cause glucose metabolism disorders by altering the gut microbiota and its metabolites, leading to insulin resistance and an increased risk of complications. Decreased levels of Lactobacillaceae and indole-3-acetic acid (IAA) are associated with these complications, while the abundance of Lactobacillaceae and IAA is negatively correlated with insulin resistance and serum lipopolysaccharide levels. IAA activates the aryl hydrocarbon receptor and increases glucagon-like peptide-1 secretion, preventing TPN-induced glucose metabolism disorders in mice.
Article
Chemistry, Organic
Yi-Zhan Wang, Shao-Dong Liu, Liang Cheng, Li Liu, Chao-Jun Li
Summary: An asymmetric umpolung addition of hydrazones as alkyl carbanion equivalents with imines in water was developed using a Ru-diamine-diphosphine system in the presence of crown ether. Chiral amines were obtained in moderate to good yields with high enantioselectivities. The use of water as a reaction medium provided better yields and enantioselectivities compared to organic solvents, offering a new method for the green and sustainable synthesis of chiral amines.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Cell Biology
Chuanming Liu, Wu Zuo, Guijun Yan, Shanshan Wang, Simin Sun, Shiyuan Li, Xinyi Tang, Yifan Li, Changjun Cai, Haiquan Wang, Wenwen Liu, Junshun Fang, Yang Zhang, Jidong Zhou, Xin Zhen, Tianxiang Feng, Yali Hu, Zhenbo Wang, Chaojun Li, Qian Bian, Haixiang Sun, Lijun Ding
Summary: With aging, abnormalities during oocyte meiosis become more prevalent, and the mechanisms of aging-related oocyte aneuploidy are not fully understood. This study reveals that disruptions in the mevalonate (MVA) pathway in granulosa cells (GCs) contribute to meiotic defects and aneuploidy in oocytes. Supplementation with MVA metabolites improves oocyte quality, suggesting a potential therapeutic strategy for promoting female reproductive longevity.
Article
Pediatrics
Lingyu Lai, Yong Lu, Zhimin Xi, Fang Liu, Liling Qian, Libo Wang, Quming Zhao
Summary: This article reports two cases of bronchial Dieulafoy's disease in children, causing recurrent massive hemoptysis. The disease was diagnosed through imaging examinations and bronchial arteriography, and was successfully treated with bronchial artery embolization, with no recurrence of hemoptysis.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Construction & Building Technology
Youmei Zhou, Hao Lei, Xiyu Zhang, Shan Wang, Yingying Xu, Chao Li, Jie Zhang
Summary: This research explores how to incorporate social attributes and social interaction into scenario simulation in the digital twin city research and development, which is a problem to be addressed in the refinement and planning of future digital platforms and management in terms of decision-making. The findings have important implications for inspiring the application of computational decision-making support in urban governance and enhancing comprehensive and sustainable urban regeneration.
