期刊
ORGANIC LETTERS
卷 14, 期 22, 页码 5632-5635出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol302409g
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-
资金
- National Institutes of Health [NIH R01 GM-033049]
An efficient synthesis of the C13-C29 fragment of amphidinolide N is described. The synthesis relies on a new strategy involving Pd-catalyzed asymmetric allylic alkylation to generate diastereoselectively the cis- or trans-THF unit simply by varying the enantiomer of the ligand. The C19 hydroxyl-bearing stereocenter was introduced using a chelation-controlled allylation which led exclusively to a single diastereoisomer.
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