期刊
ORGANIC LETTERS
卷 14, 期 12, 页码 3016-3019出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol301083q
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资金
- NSF-GRFP
- National Science Foundation
- National Institute of General Medical Sciences, National Institutes of Health [GM-36700]
- Australian Research Council [DP0985623]
- ARC Centre of Excellence for Free Radical Chemistry and Biotechnology
- University of Melbourne School of Chemistry
- UCLA AGEP
- Australian Research Council [DP0985623] Funding Source: Australian Research Council
Unlike normal Diels-Alder reactions of acyclic alkadienes with alkenes, the vinylbicyclo[2.2.2]octene employed in the Baran total synthesis of vinigrol undergoes a quantitative Diels-Alder reaction with a tethered alkene at room temperature. Density functional theory calculations reveal that this unprecedented reactivity originates from a combination of preorganization, diene strain, and tether stabilization.
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