期刊
ORGANIC LETTERS
卷 14, 期 24, 页码 6310-6313出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303057a
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资金
- Sunderland Pharmacy School
- Medical Research Council [G0802079] Funding Source: researchfish
- MRC [G0802079, G0801956] Funding Source: UKRI
The first total synthesis of the marine natural products Psammaplin C and Tokaradine A is described. Benzylidene rhodanines were utilized as versatile intermediates toward the synthesis of seven brominated marine sponge metabolites through the optimization of protection group strategies. Spermatinamine demonstrated good inhibition of all cancer cell lines tested, in particular the leukemia K562 and colon cancer HT29 cell lines.
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