期刊
ORGANIC LETTERS
卷 13, 期 4, 页码 584-587出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol102757v
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资金
- NHLBI NIH HHS [R01 HL058114-08, R01 HL058114-05A1] Funding Source: Medline
Catalytic Pd(OAc)(2) and polymethylhydrosiloxane (PMHS), in conjunction with aqueous KF, and a catalytic amount of an aromatic chloride, effects the chemo-, regio-, and stereoselective deoxygenation of benzylic oxygenated substrates at room temperature in THF. Preliminary mechanistic experiments suggest the process to involve palladium-nanoparticle-catalyzed hydrosilylation followed by C-O reduction. The chloroarene additive appears to facilitate the hydrogenolysis process through the slow controlled release of HCI.
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