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卷 13, 期 5, 页码 1036-1039出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol103088r
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- EPSRC
The olefin cross-metathesis reaction provides a rapid and efficient method for the synthesis of alpha,beta-unsaturated 1,5-dicarbonyl derivatives which then serve as effective precursors to mono-tetrasubstituted pyridines. Manipulation of the key 1,5-dicarbonyl intermediate allows access to pyridines with a wide range of substitution patterns. An extension of this methodology facilitates the preparation of pyridines embedded within macrocycles, as exemplified by an efficient synthesis of (R)-(+)-muscopyridine. High levels of regiocontrol, short reaction sequences, and facile substituent variation are all notable aspects of this methodology.
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