4.8 Article

Ruthenium-Catalyzed γ-Carbolinium Ion Formation from Aryl Azides; Synthesis of Dimebolin

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ORGANIC LETTERS
卷 13, 期 10, 页码 2726-2729

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AMER CHEMICAL SOC
DOI: 10.1021/ol2008268

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  1. NIGMS NIH HHS [R01 GM084945-03, R01GM084945, R01 GM084945-04, R01 GM084945] Funding Source: Medline

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A range of gamma-carbolines were produced stereoselectively from ruthenium(III)-catalyzed reactions of 3-pyridyl substituted aryl azides. Other catalysts and conditions were neither as selective nor as high-yielding. This method was used to synthesize dimebolin in a concise and efficient manner.

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