期刊
ORGANIC LETTERS
卷 13, 期 8, 页码 2068-2070出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol200434a
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20002004]
- Research Foundation for Pharmaceutical Sciences
- Grants-in-Aid for Scientific Research [20002004] Funding Source: KAKEN
A highly practical stereoselective total synthesis of (-)-kainic acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerizaion. This synthetic route enabled us to obtain 14.6 g of (-)-kainic acid.
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