Review
Chemistry, Organic
Muhammad Salman Javaid, Zulfiqar Ali Khan, Asim Mansha, Sohail Anjum Shahzad
Summary: Iodocarbocyclization reactions have been widely applied in synthetic organic chemistry in the past few decades, leading to the synthesis of a variety of carbocycles and heterocycles. This review highlights the important role of iodocarbocyclization reactions in synthetic organic chemistry.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Maryam Sobhani, Anna Frey, Andre Rettmann, Richard Thom, Alexander Villinger, Peter Ehlers, Peter Langer
Summary: Dibenzocycloheptanones were synthesized via Bronsted acid mediated intramolecular alkyne-carbonyl metathesis reactions, using readily available cyclization precursors. This method is highly modular, atom economic, and can construct two regioisomeric series of dibenzotropones.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xinyi Chen, Andrey Shatskiy, Jian-Quan Liu, Markus D. Karkas, Xiang-Shan Wang
Summary: An unprecedented copper-catalyzed heteroaromatization/sulfonyl transfer of propargylic alcohols with isocyanide has been developed, resulting in the production of 3-sulfonyl benzofurans and indoles under Cu(I) catalysis in good to high yields. The developed catalytic methodology provides controlled, modular, and facile access to sulfonyl benzoheterocycle scaffolds.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Organic
Si-Si Ning, Dan Meng, Jie-Yun Zhang, Shi-Lei Liu, Ni-Ni Zhou, Xiaojie Jin, Hai-Tao Zhu
Summary: A metal-free intramolecular [3+2] cycloaddtion of benzene-linked propynol-ynes in AcOH/H2O has provided a greener and more practical route to functionalized naphtho[1,2-c]furan-5-ones with high regioselectivity. Additionally, regioselective alpha-deuteration of the naphtho[1,2-c]furan-5-ones showed excellent deuterium incorporation and yields. The fluorescent properties of the naphtho[1,2-c]furan-5-one products were also investigated in solution.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Zhiqiong Tang, Fang Zhang, Tengfei Yao, Xun-Shen Liu, Yuanyuan Liu, Lu Liu
Summary: This paper presents a dearomative iodocyclization of N-(o-alkynyl)aryl isoindole, which leads to the formation of various biologically active benzoindoleazine skeletons containing alkenyl iodine. The resulting products can undergo further cycloaddition or coupling reactions to form a series of highly functionalized N-fused polycyclic scaffolds.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Stefano Barranco, Federico Cuccu, Dayi Liu, Sylvie Robin, Regis Guillot, Francesco Secci, Valerie Brenner, Michel Mons, Pierluigi Caboni, David J. Aitken, Angelo Frongia
Summary: A new method for the stereoselective one-pot double derivatization of cyclobutene-1-carboxylic acid has been developed. This method involves a mild organic base catalyzed amidation/aza-Michael addition of benzo[d]oxazol-2(3H)-ones, leading to the formation of novel beta-N-heterocyclic cyclobutane carboximide derivatives with a trans geometry. The carboximide moiety can react smoothly with nucleophiles, providing access to diverse derivatives of trans-beta-N-heterocyclic cyclobutanecarboxylic acid, including peptidomimetic structures.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yaoyu Liang, Jie Luo, David Milstein
Summary: In this study, a new reaction of acceptorless dehydrogenative coupling of epoxides and amines to form amides catalyzed by ruthenium pincer complexes is reported. This reaction shows high yield and selectivity, and is significant in various academic and industrial fields.
Article
Chemistry, Organic
Paola S. Hellwig, Angelita M. Barcellos, Roberta Cargnelutti, Thiago Barcellos, Gelson Perin
Summary: In this study, we report for the first time the synthesis method of 2(chalcogenyl)-3H-benzo[f ]chromenes and the new 3-(phenylselanyl)-2H-chromenes through radical or electrophilic cyclization. The results showed high synthetic yields and broad substrate scope for the preparation of various chalcogenylchromenes.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Surabhi Mishra, Sindoori R. Nair, Beeraiah Baire
Summary: Propargylic alcohols play a significant role in organic synthesis, allowing for the rapid and efficient generation of polycyclic systems such as pyridines, quinolines, and isoquinolines, which are important in biological activities and drug research.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Qixue Qin, Zengrui Cheng, Ning Jiao
Summary: Trifluoromethanesulfonic anhydride (Tf2O) is widely used in synthetic organic chemistry for various conversions and activations. It has shown promising results as an activator for nitrogen-containing heterocycles, nitriles, and nitro groups. Additionally, Tf2O is an efficient reagent for radical trifluoromethylation and trifluoromethylthiolation reactions. This review summarizes the recent progress and potential applications of Tf2O in organic synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Jiru Shao, Caiyun An, Sunewang R. Wang
Summary: This study reports an easy method for synthesizing polysubstituted 2-pyrones from readily available 2-acylcyclopropane-1-aryl-1-carboxylates mediated by TfOH, with a key role played by the strongly donating 1-aryl group in directing the C-C bond cleavage of the donor-acceptor cyclopropane ring to form the 2-pyrone ring through lactonization.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Organic
Yuling Lu, Jiale Zhang, Xianxian Duan, Boyi Yang, Chunhua Zhao, Lianghu Gu, Chunmei Chen, Hucheng Zhu, Ying Ye, Zengwei Luo, Yonghui Zhang
Summary: A novel and convenient K2S2O8-mediated diiodo cyclization of 1,6-enynes for the facile synthesis of functionalized gamma-lactam derivatives has been developed. This reaction features mild and transition-metal-free conditions, which offer a green and efficient entry to synthetically important gamma-lactam scaffolds. Mechanistic studies suggest that iodide radicals initiate the cascade cyclic transformation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Raji Reddy Chada, Roshan Chandrakant Kajare, Mayur C. Bhandari, Siddique Z. Mohammed, Mahender Khatravath, Kamalkishor Warudikar, Nagender Punna
Summary: An efficient method has been developed for the highly diastereoselective construction of functionalized cyclopenta[d][1,2]oxazines through sequential oxyamination and Pauson-Khand reaction of readily accessible propargylic alcohols. Additionally, the ring closing metathesis of these N-O linked 1,7-enynes yielded vinylated-[1,2]oxazines in good yields. The reduction of the N-O bond in the obtained cyclopenta[d][1,2]oxazine allows access to cyclopentenone-based amino alcohols.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Srinivasarao Yaragorla, Dandugula Sneha Latha
Summary: A new method has been reported for the selective reaction of C-C double bonds and C-C triple bonds in the presence of a catalyst, leading to the efficient synthesis of functionalized thiazoles. The reaction also exhibits stereoselectivity and time-dependent formation of products.
Article
Chemistry, Organic
Satheeshvarma Vanaparthi, Mamta, Jyothi Yadav, Amol Prakash Pawar, Eldhose Iype, Sravendra Rana, Indresh Kumar
Summary: A two-pot synthesis of 5-aza-indoles has been achieved using aqueous succinaldehyde and N-aryl propargylic-imines, involving a metal-free annulation and Ag-catalyzed cyclization. The resulting 5-aza-indoles exhibit interesting photophysical activities, and the feasibility of this economically viable gram-scale synthesis has been demonstrated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
Zi-Sheng Chen, Xiao-Yan Huang, Qing Liu, De-Xin Song, Fang Yang, Kegong Ji
Summary: This article presents a synergistic Rh(II)/Pd(0) dual-catalyzed strategy for the three-component oxy-allylation of a-diazo esters, alcohols, and allylic benzoates. The reaction involves the trapping of active protic oxonium ylides with catalytic p-allyl Pd(II) intermediates. Interestingly, water also participates in the reaction through a different allylic migratory insertion of palladium-carbenes. These transformations offer a straightforward approach to various a-ternary allylated carboxylic esters using readily available starting materials under redox-neutral conditions, leading to the successive generation of two new C-O and C-C bonds at the carbene center. CO 2022 Elsevier Inc. All rights reserved.
JOURNAL OF CATALYSIS
(2023)
Article
Mathematics, Applied
Mairaj Bibi, Sajid Ali, Muhammad Shoaib Arif, Kamaleldin Abodayeh
Summary: In [1], Bibi and Edjvet demonstrated that any equation with a length of at most seven over torsion-free group can be solved. This supports Levin's [2] assertion that any equation over a torsion-free group is solvable. This article demonstrates that a singular equation of length eight over torsion-free groups is solvable.
Article
Business, Finance
Yue Sheng Chen, Zhong Chen, Sajid Ali, Muhammad Imdad Ullah, Muhammad Khalid Anser
Summary: This research investigates the impact of financial inclusion on foreign direct investment (FDI) in East Asia and Pacific (EAP) countries. Traditional econometric methods fail to consider cross-sectional dependence and heterogeneity among countries, leading to biased estimates. Using the unique method called DCCE, the study finds that financial inclusion positively and significantly affects FDI in higher-income and overall EAP countries. In lower-income EAP countries, financial inclusion has an insignificant correlation with FDI, which becomes significant when an interaction term for institutional performance and financial inclusion is included. Therefore, policymakers should focus on increasing financial inclusion to attract FDI and promote economic growth in EAP economies.
BORSA ISTANBUL REVIEW
(2023)
Article
Pharmacology & Pharmacy
Nida Shakir, Ali Sharif, Sajid Ali, Bushra Akhtar, Muhammad Furqan Akhtar, Faqir Muhammad, Ammara Saleem, Kanwal Akhtar, Imran Tariq, Muhammad Imran Khan
Summary: This study evaluated the acute and chronic toxicity of Pirarubicin loaded PLGA nanoparticles (PRB-NP). The nanoparticles did not affect the behavioral pattern, food, water consumption or body weights of the rats. The abnormalities in function and morphology of the organs produced by PRB-NP were dose-dependent and reversible.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Hasan Sardar, Muhammad Arif Ramzan, Safina Naz, Sajid Ali, Shaghef Ejaz, Riaz Ahmad, Muhammad Ahsan Altaf
Summary: Salt accumulation in irrigated soils is a worldwide hazard that affects crop productivity. Broccoli is moderately tolerant to salinity. The application of exogenous melatonin improved the morphological characteristics and biochemical composition of broccoli under salt stress.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Biochemistry & Molecular Biology
Sajid Ali, Pierre Gladieux, Sebastien Ravel, Henri Adreit, Isabelle Meusnier, Joelle Milazzo, Sandrine Cros-Arteil, Francois Bonnot, Baihui Jin, Thomas Dumartinet, Florian Charriat, Alexandre Lassagne, Xiahong He, Didier Tharreau, Huichuan Huang, Jean-Benoit Morel, Elisabeth Fournier
Summary: By investigating the genetic and phenotypic relationship between rice landraces and their rice blast pathogen in traditional flooded rice paddies, it was found that specific lineages of rice blast coexisted in the Yuanyang terraces. The study suggests that disease control strategies based on the emergence or maintenance of a generalist lifestyle in pathogens may sustainably reduce the burden of disease in crops.
Article
Biochemistry & Molecular Biology
Sajid Ali, Nazma Faqir, Falak Naz, Muhammad Ishtiaq Jan, Naeem Khan, Amal Alotaibi, Riaz Ullah
Summary: The study found that complexes 1 and 2 can effectively inhibit the formation of bacterial biofilms and cause damage to the bacterial membrane. The minimum inhibitory concentration and minimum bactericidal concentration of complexes 1 and 2 were 46.87 +/- 1.822 and 93.75 +/- 1.345 and 47.87 +/- 1.345 and 94.85 +/- 1.466 mu g/mL, respectively. Both complexes also showed good interactions with E. coli DNA. Therefore, complexes 1 and 2 are good antibiofilm agents that can restrict the development of bacterial biofilms on therapeutic implants by disrupting the bacterial membrane and interacting with bacterial DNA.
Article
Environmental Sciences
Meilan Chen, Wenfeng Huang, Sajid Ali
Summary: Renewable energy is gaining popularity due to its cost-effectiveness. This study examines the asymmetric link between wind energy and ecological footprint in the top-10 wind energy-consumer economies. The results show that wind energy consumption reduces ecological footprint in most sample nations, except for Spain and India. The degree of the asymmetric association varies by country, highlighting the need for individualized government policies in promoting wind energy and ecological sustainability.
ENVIRONMENTAL DEVELOPMENT
(2023)
Article
Agronomy
Nighat Seema, Muhammad Hamayun, Anwar Hussain, Mohib Shah, Muhammad Irshad, Muhammad Qadir, Amjad Iqbal, Abdulwahed Fahad Alrefaei, Sajid Ali
Summary: The aim of this study was to isolate endophytes from the roots of Rhazya stricta and evaluate their potential in improving the growth of drought-stressed sunflower seedlings. The isolated endophytic fungus was found to enhance the growth attributes of rice varieties and contribute to the improvement of sunflower growth under drought stress. The fungal strain was identified as Fusarium proliferatum and its beneficial effects were attributed to the regulation of phytohormones and stress-related metabolites.
Article
Agronomy
Muhammad Musa, Farzana Gul Jan, Muhammad Hamayun, Gul Jan, Sumera Afzal Khan, Gauhar Rehman, Sajid Ali, In-Jung Lee
Summary: Heavy metal contamination in soil and accumulation in plants pose a serious threat to crops and human health. Endophytic fungi can enhance the plant's ability to tolerate stressful conditions. The present study found that the endophytic fungus Paecilomyces lilacinus (MRF) isolated from the roots of Justicia adathoda has the capability to alleviate heavy metal stress and improve the growth and physiological characteristics of tomatoes.
Article
Chemistry, Organic
Wen-Shuai Chen, Fang Yang, Ting Wang, Gang-Qiong Zhang, Yi Wei, Mo-Han Wang, Zi-Sheng Chen, Kegong Ji
Summary: An efficient and chemoselective method for the transformation of β-amidoyne to 3-acyl-substituted quinolones 2 and 3-H-quinolones 4 has been developed. The reaction involves the selective C=O bond cleavage, 1,5-O migration, and C=C bond recombination process of β-cyclic amidoyne, leading to the selective formation of quinolones 2. This practical approach provides a viable alternative for the synthesis of various quinolones.
Review
Chemistry, Multidisciplinary
Shujat Ali, Xi Chen, Shujaat Ahmad, Mazen Almehmadi, Ahad Amer Alsaiari, Mamdouh Allahyani, Zarif Gul, Abid Ullah, Haya Hussain, Limin Li, Xiaojing Chen
Summary: Gold bimetallic nanostructures (AuBMNS) show better Hg sensing activity than their monometallic counterparts and their performance depends on shape, size, composition, and surface chemistry. However, there is a lack of review papers on the morphology-controlled synthesis of AuBMNS and their application in Hg detection. This article aims to provide a clear understanding of the shape/size-controlled preparation, functionalization, and morphology-dependent application of AuBMNS in Hg detection.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Environmental Sciences
Sun Guoyan, Asadullah Khaskheli, Syed Ali Raza, Sajid Ali
Summary: According to the United Nations Agenda, a sustainable environment is crucial for the future of the planet in 2023, and investment in energy through public-private partnerships is essential for sustainable development. The research examines the relationship between public-private partnership ventures in energy and environmental degradation in ten developing nations. The findings show a positive association in Argentina, Brazil, Bangladesh, and India, while a negative relationship is observed in China, Malaysia, Mexico, Peru, Thailand, and the Philippines.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Afshan Asghar, Ali Sharif, Sana Javaid Awan, Bushra Akhtar, Muhammad Furqan Akhtar, Sajid Ali, Shahnaz
Summary: This study investigated the anti-diabetic effects of the ethanolic extract of Ficus johannis leaves and found that it exhibited strong antioxidant and alpha-amylase inhibitory activities. The extract contained high levels of phenolic and flavonoid compounds, with gallic acid being the main constituent. Animal experiments showed that the extract improved insulin sensitivity, glucose transporter 4 translocation, and carbohydrate metabolism, while inhibiting lipogenesis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Rashid Jawad, Aamir Nawaz, Shaghef Ejaz, Sajid Ali, Muhammad Shahzad Saleem, Hafiz Mohkum Hammad
Summary: Sewage water (SW) causes heavy metal accumulation in soil, particularly lead contamination, which affects plant growth and produce quality. Pot experiments were conducted to study the effects of zeolite soil amendment on tomato plants grown with SW irrigation. Results showed that the application of 0.75% zeolite improved plant growth attributes and decreased lead accumulation compared to SW-irrigated plants. Zeolite treatment also increased chlorophyll content and physiological traits in the plants. This study highlights the potential of zeolite as a soil amendment to mitigate the negative effects of SW irrigation on crop growth and metal accumulation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
