期刊
ORGANIC LETTERS
卷 13, 期 6, 页码 1494-1497出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol200185h
关键词
-
资金
- NSFC [90813012, 20932003]
- National S&T Major Project of China [2009ZX09503-017]
An easily prepared cinchona alkaloid derivative was found to be an effective organocatalyst in a direct, enantioselective aza-Mannich addition. By establishing a quaternary carbon stereocenter, a series of modified chiral 2-(ethylthio)-thiazolone derivatives have been obtained with excellent diastereo- and enantioselectivities. And these derivatives have been found to show anticancer activities against five different cancer cell lines using the MTT assay.
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