4.8 Article

A Concise Total Synthesis of (±)-Minfiensine

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ORGANIC LETTERS
卷 13, 期 24, 页码 6426-6428

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AMER CHEMICAL SOC
DOI: 10.1021/ol2027224

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资金

  1. National Natural Science Foundation of China [21072191]
  2. Guangzhou Institutes of Biomedicine and Health

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A concise total synthesis of (+/-)-minfiensine using all conventional methods and starting from commercial materials has been completed. The synthesis features a Fischer indole synthesis, a Heck alkylation of an intermediate ketone enolate, conversion of a ketone carbonyl into an epoxide, and transformation of the latter into an allylic alcohol.

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