☆ 4.8 Article

Rapid Assembly of the Salvileucalin B Norcaradiene Core

ORGANIC LETTERS (2010)

期刊

ORGANIC LETTERS

卷 12, 期 4, 页码 780-783

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AMER CHEMICAL SOC

DOI: 10.1021/ol902848k

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Chemistry, Organic

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California Institute of Technology

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Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.

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