4.8 Article

One-Pot Highly Diastereoselective Synthesis of cis-Vinylaziridines via the Sulfur Ylide-Mediated Aziridination and Palladium(0)-Catalyzed Isomerization

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ORGANIC LETTERS
卷 12, 期 3, 页码 504-507

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AMER CHEMICAL SOC
DOI: 10.1021/ol9027072

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资金

  1. National Natural Sciences Foundation of China [20821002, 20672131]
  2. Major State Basic Research Development Program [2006CB806105]
  3. Chinese Academy of Sciences

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Highly diastereoselective synthesis of cis-trisubstituted vinylaziridines containing a quaternary carbon center is realized by a one-pot protocol in which the combination of sulfur ylide-mediated aziridination of cyclic ketimines and Pd(0)-catalyzed isomerization is employed successfully.

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