Article
Chemistry, Multidisciplinary
Gege Qiu, Paola Nava, Alexandre Martinez, Cedric Colomban
Summary: Hm-TBTA, equipped with a bowl-shaped cap, accelerates CuAAC reactions without product inhibition and efficiently protects the copper center from deactivation by the Cu-I-chelator glutathione, offering novel approaches for efficient CuAAC reactions in complex media.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hussein Al-Mughaid, Younis Jaradat, Maha Khazaaleh, Ibrahim Al-Taani
Summary: An efficient one-pot synthesis of a new series of mannosyl triazoles has been achieved, and their inhibitory potency against FimH has been evaluated, showing that the length of four methylene units is the most suitable.
CARBOHYDRATE RESEARCH
(2023)
Article
Chemistry, Analytical
Fei Zeng, Yongchun Pan, Xiaowei Luan, Yanfeng Gao, Jingjing Yang, Yuzhen Wang, Yujun Song
Summary: The study constructed a glutathione-triggered nanoreactor that accelerates bioorthogonal reactions. The nanoreactor shows good biocompatibility in detecting glutathione in cells and wheat plumules, and has potential for detecting metal ions in plants. Monitoring bioorthogonal reactions intracellularly may contribute to precision chemistry and smart platform design for biomarker detection and targeted drug manufacture.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Robert W. Pipal, Kenneth T. Stout, Patricia Z. Musacchio, Sumei Ren, Thomas J. A. Graham, Stefan Verhoog, Liza Gantert, Talakad G. Lohith, Alexander Schmitz, Hsiaoju S. Lee, David Hesk, Eric D. Hostetler, Ian W. Davies, David W. C. MacMillan
Summary: By utilizing a versatile and rapid metallaphotoredox-catalysed method, both tritium and carbon-11 can be efficiently introduced into pharmaceutical precursors bearing aryl and alkyl bromides, simplifying the synthesis of radioligands and expanding their applicability. This technique has direct utility for preclinical PET imaging and translation to automated radiosynthesis, demonstrating its potential for routine radiotracer production in human clinical imaging.
Article
Polymer Science
Nick Huettner, Tim R. Dargaville, Neha S. Gandhi
Summary: The synthesis of cyclic polymers has made great progress, but upscaling remains a challenge. Experimental screening of reaction parameters is currently necessary to achieve acceptable cyclization yields. The influence of polymer structure on cyclization process is often overlooked. Using molecular dynamics simulations, we compared the properties of different polymers and demonstrated the importance of polymer structure in cyclization reactions.
Article
Polymer Science
Xueyan Dai, Peihong Li, Yanlong Sui, Chunling Zhang
Summary: By introducing a flexible segment via thiol-ene click reaction, a toughened, flexible, and hydrophobic epoxy resin was successfully synthesized. The sample with 75% DGEBDBP and 25% E44 exhibited the highest breaking elongation, compressive strength, and contact angle. The introduction of side chains through the thiol-ene click reaction provides a simple and effective method for designing multifunctional epoxy resins.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Liang Zheng, Yiwen Zhu, Yujie Sun, Shuai Xia, Shun Duan, Bingran Yu, Jing Li, Fu-Jian Xu
Summary: This study successfully designed and synthesized a series of cationic aggregation-induced emission (AIE) derivatives (CABs) for flexible modulation of cellular activities. By regulating the length of alkyl chains, different binding, localization, and photodynamic killing effects of CABs were achieved and systematically investigated among bacteria, fungi, and mammalian cells. The study found that intracellular active substances, rather than cell membranes, are more efficient damage sites for antimicrobial photodynamic therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Bin Deng, Jing Yang, Mengbi Guo, Rui Yang
Summary: A series of cyclodextrin-based supramolecular polymers were constructed and used as ligands in copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) for the first time. The CD-SP 4 self-assembly showed highly efficient catalytic activity and can be fully recycled, extending the potential applications of cyclodextrin-based supramolecular polymers in green chemical synthesis.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mingjuan Zhang, Jinxi Xu, Tianzhu Zhang, Yiqun Li
Summary: A novel copper immobilized on biomimetic assembled carboxymethylcellulose/calcium carbonate hybrid (Cu-II@CMC/CaCO3) has been successfully prepared as an efficient catalyst for synthesizing 1,2,3-triazoles. The Cu-II@CMC/CaCO3 hybrid, characterized by various techniques, exhibited high catalytic activity and stability, with the ability to be conveniently recovered and reused multiple times without significant loss in performance. The success of this catalyst can be attributed to the coordination of carboxyl and hydroxyl groups in the CMC/CaCO3 hybrid.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Chemistry, Applied
Melisa Trejo-Maldonado, Luis Ernesto Elizalde, Benjamin Le Droumaguet, Daniel Grande
Summary: A versatile approach was developed for the preparation of porous polystyrene frameworks functionalized with triazolyl moieties. The porous materials were synthesized from PLA-b-P(S-stat-4-AMS) diblock copolymer precursors and characterized by various analytical techniques. Functionalization of the materials with p-tolylacetylene or 2-methyl-3-butyn-2-ol was achieved via copper-catalyzed azide-alkyne cycloaddition, resulting in high yields of the triazole ring.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Chen-Yo Fan, Sachin Kisan Kawade, Avijit K. Adak, Chien Cho, Kui-Thong Tan, Chun-Cheng Lin
Summary: The fabrication of Ag-coated cuprous oxide (Cu2O) NP slides promotes metal-enhanced fluorescence effect and enables external copper ion-free CuAAC reaction, providing a practical and alternative sensing platform for biological or diagnostic applications; the immobilization of antibodies on these newly developed slide surfaces using a specific pathway shows better sensitivity compared to the random antibody immobilization method.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Seungki Shin, Yoonkyu Kim, Namyoung Gwak, Inyoung Jeong, Minwoo Lee, Kyungwan Kang, Sooyeon Yeon, Seongchan Kim, Tae Ann Kim, Nuri Oh
Summary: The solution processability of colloidal perovskite nanocrystals (PNCs) provides versatility in the device fabrication process. However, the low solvent resistance of PNCs hinders their use in all-solution processes. In this study, the authors demonstrate a strategy for improving the solvent resistance of PNC films and forming desired patterns through ligand polymerization. They also show the direct photopatterning of PNC films by manipulating the selectivity of ligand polymerization.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Katherine Stewart, Katia Pagano, Ellasia Tan, Matyas Daboczi, Martina Rimmele, Joel Luke, Salvador Eslava, Ji-Seon Kim
Summary: This study investigates the effect of minor modifications to side-chain density on polaron formation in organic semiconductors and demonstrates their impact on the electrical response of polymers in gas sensing. The results show that reducing side-chain density leads to a multistep polaron formation and allows for the formation of a higher density of polarons with fewer structural changes. More numerous but more localized polarons generate a stronger analyte response but lack selectivity between polar and non-polar solvents, while more delocalized polarons show clear selectivity.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxia Yao, Jilong Zhang, Yifei Zhu
Summary: The concerted elimination reaction class of peroxyl-hydroperoxyl alkyl radicals plays a crucial role in low-temperature combustion. By dividing reactions into subclasses and calculating energy barriers, accurate rate constants and rules are obtained to aid in constructing more accurate combustion mechanisms.
Article
Engineering, Environmental
Jinlong Liu, Juanxiu Xiao, Bingcheng Luo, Enke Tian, Geoffrey I. N. Waterhouse
Summary: By using density functional theory calculations, it was found that the central metal and coordinating atoms strongly influence the oxygen electrocatalysis activity on metal single-atom catalysts, primarily by tuning the adsorption free energy of adsorbed hydroxyl. Dual limiting potential volcano curves were constructed, with Ni-N2-C identified as the optimal synthetic target for bifunctional ORR/OER electrocatalysis.
CHEMICAL ENGINEERING JOURNAL
(2022)
