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Concise Formal Total Synthesis of Platensimycin Mediated by a Stereoselective Autoxidation and Hydroxyl Group Directed Conjugative Reduction

ORGANIC LETTERS (2010)

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ORGANIC LETTERS

卷 12, 期 24, 页码 5677-5679

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AMER CHEMICAL SOC

DOI: 10.1021/ol102557k

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Chemistry, Organic

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Welch Chair [F-0018]

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The synthesis of 13, an advanced intermediate in the Nicolaou synthesis of platensimycin 1, was made from 9 by autoxidation to give 10, which was stereoselectively reduced providing 12. Finally, dehydration of 12 by heating in DMSO resulted in

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