☆ 4.8 Article

Enantiopure 1,2-Bis(tert-butylmethylphosphino)benzene as a Highly Efficient Ligand in Rhodium-Catalyzed Asymmetric Hydrogenation

ORGANIC LETTERS (2010)

期刊

ORGANIC LETTERS

卷 12, 期 19, 页码 4400-4403

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AMER CHEMICAL SOC

DOI: 10.1021/ol101936w

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Chemistry, Organic

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An electron-rich P-stereogenic bisphosphine ligand named BenzP(star) was conveniently prepared from o-dibromobenzene and enantiopure tert-butylmethylphosphine-borane. Its rhodium complex exhibited excellent enantioselectivities of up to 99.9% and high catalytic activity of up to 10 000 h(-1) TOE in asymmetric hydrogenations of various functionalized alkenes.

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