期刊
ORGANIC LETTERS
卷 12, 期 6, 页码 1168-1171出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9028995
关键词
-
资金
- National Natural Science Foundation [30630072, 30721005, 20932007]
- National Science & Technology Major Project [2009ZX09301-001]
- People's Republic of China
Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method, X-ray crystallography, and CD analysis. This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently. Compound 3 showed significant inhibition against MET tyrosine kinase activity with a IC50 value of 1.95 mu M.
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