Per-6-amino-β-cyclodextrin as a Reusable Promoter and Chiral Host for Enantioselective Henry Reaction

A highly efficient enantioselective Henry reaction has been carried out using per-6-ABCD as a supramolecular chiral host and promoter to give the corresponding adduct with high yield (up to 99%) and enantiomeric excess (up to 99%). Per-6-ABCD also promotes the diastereoselective Henry reaction in a syn-selective manner to give the adduct up to 99% yield with 99:1 syn/anti selectivity. The enantiomeric excess of the syn-adduct is 99%. The catalyst is recovered and reused without loss in its activity.