期刊
ORGANIC LETTERS
卷 12, 期 11, 页码 2488-2491出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol100450s
关键词
-
资金
- Japan Society for the Promotion of Science (JSPS)
- Global COE Program
- University of Tokyo
- MEXT, Japan
In(1)OTf has been uncovered as an effective Lewis acid catalyst for unprecedented nucleophilic substitution of acetals or ketals with allylboronates. A transmetalative S(N)1 mechanism is proposed in which a single In(1) center acts as a dual catalyst to activate both reagents sequentially. Contrary to the classic gamma-selectivity of allylsilanes (Hosomi-Sakurai reaction), this In(1)-catalyzed borono variant displays distinct alpha-selectivity. Substrate scope and functional group tolerance proved to be excellent.
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