期刊
ORGANIC LETTERS
卷 11, 期 10, 页码 2209-2212出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol900594h
关键词
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资金
- NIH-NIGMS [GM071650]
- Camille and Henry Dreyfus Foundation (Camille Dreyfus Teacher Scholar Award)
- GlaxoSmithKline
- Eli Lilly
- Amgen
- 3M
A five step-synthesis of fused bis-tetrahydrofurans and attached bis-tetrahydrofurans from butadiene diepoxide is described. Two sequential Pd-catalyzed carboetherification reactions between protected 1,2-diols and aryl/alkenyl bromides, each of which form both a C-O bond and a C-C bond, are used to generate the heterocyclic rings with >20:1 dr. Installation of different R-1 and R-2 groups is achieved in a straightforward fashion through use of different aryl or alkenyl bromide coupling partners.
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