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卷 11, 期 23, 页码 5546-5549出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9023985
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Reaction of aldehydes 2, anilines 3, and enecarbamates 4 In dichloromethane In the presence of EtOH and a catalytic amount of chiral phosphoric acid 5 afforded the Mannich adducts which were in situ reduced to anti-1,2-disubstituted 1,3-diamines 1 in excellent diastereoselectivity and enantioselectivity.
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