Article
Cardiac & Cardiovascular Systems
Le Geng, Jiaxi Gu, Minghui Li, Hong Liu, Haoliang Sun, Buqing Ni, Weidong Gu, Yongfeng Shao, Mingfang Li, Minglong Chen
Summary: This study aimed to evaluate the correlation between the monitoring frequency of PT-INR and the long-term prognosis in patients with mechanical heart valve replacement. The results showed that patients with less frequent monitoring of PT-INR may have worse clinical prognosis than those with frequent monitoring.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Xiliang Zhu, Xijun Xiao, Sheng Wang, Xianjie Chen, Guoqing Lu, Xiaoyang Li
Summary: This study evaluated the quality of anticoagulation in patients with a 12-week INR follow-up interval and found that female gender and atrial fibrillation were associated with TTR < 60%. A 12-week monitoring interval has an acceptable quality of anticoagulation for patients with stable international normalized ratio monitoring results in anticoagulation clinics.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Amber Afzal, Brian F. Gage, Luo Suhong, Martin W. Schoen, Kevin Korenblat, Kristen M. Sanfilippo
Summary: The relationship between INR and risk of hemorrhage is different in chronic liver disease (CLD) patients compared to warfarin users. INR has a positive correlation with hemorrhage risk in CLD patients, while in warfarin users, the risk is low in subtherapeutic and therapeutic ranges, and exponentially increases in the supratherapeutic range.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Urology & Nephrology
Theepika Rajkumar, Jeffrey Wong, Michael Harvey, Lachlan Weidersehn, Laura Surmon, Angela Makris
Summary: Good agreement and correlation were found between peripheral blood, haemodialysis access/circuit, and point-of-care INR values in dialysis patients on warfarin. Point-of-care INR was less reliable at higher values, and dosing decisions differed from peripheral INR in a quarter of cases.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Muhammet Onur Hanedan, Semiha Alkan Kayhan, Ebru Dizdar, Askin Kilic, Ali Kemal Arslan, Mehmet Ali Yuruk, Ufuk Sayar
Summary: This study compared the effects of face-to-face and telephone applications on patients' international normalized ratio (INR). The results showed that there was no significant difference in INR levels between patients monitored through telephone application and those monitored through face-to-face. Therefore, telephone application can be used for warfarin therapy management.
Article
Pharmacology & Pharmacy
Xi Zhang, Fengwei Jiao, Guangrun Li, Xiaojia Yu, Yuqing Pei, Ying Zhang, Zihui Wang, Pengfei Li
Summary: Azvudine, a potential treatment for COVID-19, has drug interactions with anticoagulants warfarin and rivaroxaban that can increase the international normalized ratio (INR). Close monitoring of INR is necessary when these drugs are used together in COVID-19 patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pediatrics
Nicoletta Erba, Sofia Gatti, Suha Abdelwahab Abdalla Hassan, Martin Langer, Liliane Chatenoud, Gina Portella, Raffaela Baiocchi
Summary: Pregnancy and childbirth after mechanical heart valve replacement with anticoagulant therapy pose a high risk for complications. The limited access to tertiary healthcare services in the area where patients live leads to unacceptable maternal mortality rates, necessitating a structured, multi-disciplinary intervention.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Yan Liang, Guiying Yang, Hong Li, Ning Ding, Lin Zhang, Jian Chen
Summary: This study aimed to determine the optimal timing of warfarin discontinuation based on different INR ranges for patients with mechanical heart valves undergoing non-cardiac surgeries. The results indicate that discontinuing warfarin for 3 days is sufficient when the preoperative INR is less than 1.5, and discontinuing warfarin for 3-5 days is appropriate when the INR is less than 1.2. Furthermore, the change in INR after warfarin discontinuation does not significantly affect intraoperative bleeding in non-cardiac surgeries.
Article
Cardiac & Cardiovascular Systems
Radwa Ahmed Batran, Nagwa Ali Sabri, Ihab Ali, Sarah Farid Fahmy
Summary: This study aimed to assess the clinical and cost-effectiveness of adopting pharmacist-managed warfarin therapy (PMWT) services for optimizing warfarin treatment in Egypt. The results showed that the PMWT strategy significantly improved anticoagulation control and was cost-saving in Egyptian patients with mechanical mitral valve prostheses (MMVPs).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Toshinori Hirai, Takahiko Aoyama, Yasuhiro Tsuji, Toshimasa Itoh, Yoshiaki Matsumoto, Takuya Iwamoto
Summary: Genotype-guided dosing algorithms can explain a significant portion of interindividual variability in PT-INR under warfarin treatment. By refining a kinetic-pharmacodynamic model and considering factors such as age and renal function, optimal warfarin dosage can be determined to achieve target PT-INR levels, particularly in patients with renal impairment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Teodoro J. Oscanoa, Maria L. Guevara-Fujita, Ricardo M. Fujita, Maria Y. Munoz-Paredes, Oscar Acosta, Roman Romero-Ortuno
Summary: This study aimed to investigate the association between VKORC1 and CYP2C9 gene polymorphisms and the maintenance dose of warfarin in Peruvian patients. The results showed that the AA genotype of the VKORC1 gene was associated with a lower maintenance dose of warfarin, while no significant association was found between the CYP2C9 gene polymorphism and the dose of warfarin.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Han Zhou, Linzhi Wu, Qianqian Wu
Summary: Heart valve replacement is an effective treatment for severe valvular stenosis or insufficiency, with options of mechanical or biological valves. Fabric composite valves offer advantages of both mechanical and biological valves, allowing flexibility and wear resistance adjustments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Emiliano A. Rodriguez-Caulo, Oscar R. Blanco-Herrera, Elisabet Berastegui, Javier Arias-Dachary, Souhayla Souaf-Khalafi, Gertrudis Parody-Cuerda, Gregorio Laguna
Summary: This study compared the long-term outcomes of biological and mechanical prostheses for aortic valve replacement in patients aged 50 to 65. The results showed no significant difference in long-term survival between the two groups, but patients with mechanical prostheses had a higher risk of major bleeding while those with biological prostheses had a higher reoperation rate. Therefore, for patients in this age group in Spain, biological prostheses may be a reasonable choice.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Amila Kahrovic, Philipp Angleitner, Harald Herkner, Alfred Kocher, Marek Ehrlich, Guenther Laufer, Martin Andreas
Summary: In patients with left-sided infective endocarditis <55 years of age, implantation of a mechanical valve prosthesis is associated with superior outcomes, including lower risks of all-cause mortality and combined events.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Omar Abozied, William Miranda, Ahmed Younis, Luke Burchill, Charles Jain, Heidi Connolly, Joseph Dearani, Elizabeth H. Stephens, Alexander C. Egbe
Summary: This study aimed to assess the function and outcomes of mechanical heart valves compared to bioprosthetic valves in the same positions. The results showed that patients who received mechanical valves had lower risks of valve dysfunction but higher risks of bleeding complications.
Article
Cardiac & Cardiovascular Systems
Ashkan Labaf, Bartosz Grzymala-Lubanski, Anders Sjalander, Peter J. Svensson, Martin Stagmo
AMERICAN HEART JOURNAL
(2015)
Article
Cardiac & Cardiovascular Systems
Ashkan Labaf, Peter J. Svensson, Henrik Renlund, Anders Jeppsson, Anders Sjalander
AMERICAN HEART JOURNAL
(2016)
Article
Hematology
Ashkan Labaf, Bartosz Grzymala-Lubanski, Martin Stagmo, Susanna Lovdahl, Mattias Wieloch, Anders Sjalander, Peter J. Svensson
THROMBOSIS RESEARCH
(2014)
Article
Hematology
Bartosz Grzymala-Lubanski, Ashkan Labaf, Erling Englund, Peter J. Svensson, Anders Sjalander
THROMBOSIS RESEARCH
(2014)
Article
Medical Informatics
Artin Entezarjou, Susanna Calling, Tapomita Bhattacharyya, Veronica Milos Nymberg, Lina Vigren, Ashkan Labaf, Ulf Jakobsson, Patrik Midlov
Summary: The study found that antibiotic prescription rates were lower following eVisits compared with office visits for sore throat and respiratory symptoms, while there was no significant difference for dysuria. Additionally, guideline-recommended antibiotics were prescribed similarly following eVisits and office visits.
JMIR MEDICAL INFORMATICS
(2021)
Correction
Medical Informatics
Artin Entezarjou, Susanna Calling, Tapomita Bhattacharyya, Veronica Milos Nymberg, Lina Vigren, Ashkan Labaf, Ulf Jakobsson, Patrik Midlov
JMIR MEDICAL INFORMATICS
(2021)
Article
Hematology
Ashkan Labaf, Martin Carlwe, Peter J. Svensson
THROMBOSIS JOURNAL
(2014)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)