☆ 4.8 Article

Cu(I)-Catalyzed Diamination of Disubstituted Terminal Olefins: An Approach to Potent NK1 Antagonist

ORGANIC LETTERS (2009)

期刊

ORGANIC LETTERS

卷 11, 期 11, 页码 2365-2368

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol900808z

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Chemistry, Organic

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General Medical Sciences of the National Institutes of Health [GM083944-02]

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Reagent

摘要

This paper describes a diamination process using di-tert-butyldiaziridinone as nitrogen source and CuCl as catalyst. A wide variety of disubstituted terminal olefins can be efficiently diaminated in good yields under mild condition. This diamination process was used to synthesize potent NK1 antagonist Sch 425078.

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