☆ 4.8 Article

Chemoenzymatic Access to Versatile Epoxyquinol Synthons

ORGANIC LETTERS (2009)

期刊

ORGANIC LETTERS

卷 11, 期 19, 页码 4290-4293

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol9016657

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Chemistry, Organic

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Institute of Advanced Studies
Australian Research Council

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The enantiomerically pure and readily available metabolites 10-12 have been converted over four simple steps into the epoxyquinol derivatives 22-24, respectively. Compounds 23 and 24 or their immediate precursors have been exploited in efficient total syntheses of (-)-bromoxone (ent-1), (-)-epiepoformin (ent-2), (-)-harveynone (4), (+)-panepophenanthrin (6), and (+)-hexacyclinol (9).

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