期刊
ORGANIC LETTERS
卷 11, 期 15, 页码 3202-3205出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9010932
关键词
-
资金
- The ACS Petroleum Research Fund [5001009]
- Boston College
- NSF [DBI-0619576]
Over a century ago, the first reactions of diazomethane with aldehydes delivered methyl ketones. In the interim, aldehydes have been homologated with trimethylsilyldiazomethane, diazoacetates, and aryidiazomethanes, on rare occasion with catalysis, This work describes a mild procedure for convergent ketone assembly from nonstabilized diazoalkanes, including examples of chiral ketone synthesis with disubstituted (internal) nucleophiles, The method's remarkable tolerance to steric crowding is showcased in a simple approach to achyrofuran, a complex dibenzofuran.
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