期刊
ORGANIC LETTERS
卷 11, 期 1, 页码 193-196出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol802094p
关键词
-
资金
- NIH [AI063596]
- NIH Biotechnology Training Program [GM08349]
- Novartis Institute for BioMedical Research, Inc.
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI063596, R56AI063596] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008349] Funding Source: NIH RePORTER
UDP-Galactopyranose mutase (UGM or Glf), which catalyzes the interconversion of UDP-galactopyranose and UDP-galactofuranose, is implicated in the viability and virulence of multiple pathogenic microorganisms. Here we report the synthesis of high-affinity ligands for UGM homologues from Klebsiella pneumoniae and Mycobacterium tuberculosis. The potency of these compounds stems from their ability to access both the substrate binding pocket and an adjacent site.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据