期刊
ORGANIC LETTERS
卷 11, 期 1, 页码 225-228出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol8024814
关键词
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资金
- FIC NIH HHS [U01 TW007401-04, R21 TW006662-01, U01 TW007401-01, U01 TW007401, U01 TW007401-02, R21 TW006662-02, U01 TW007401-03, R21 TW006662, U19 TW007401] Funding Source: Medline
- FOGARTY INTERNATIONAL CENTER [U19TW007401, R21TW006662, U01TW007401] Funding Source: NIH RePORTER
Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).
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