Article
Hematology
Helen Havens Clark, Lance Ballester, Hilary Whitworth, Leslie Raffini, Char Witmer
Summary: Children with CVC-VTE are at increased risk for recurrent VTE. Secondary prophylaxis with full-dose anticoagulation was associated with a 65% reduction in odds of thrombotic events.
Article
Cardiac & Cardiovascular Systems
Maria A. de Winter, Harry R. Buller, Marc Carrier, Alexander T. Cohen, John-Bjarne Hansen, Karin A. H. Kaasjager, Ajay K. Kakkar, Saskia Middeldorp, Gary E. Raskob, Henrik T. Sorensen, Frank L. J. Visseren, Philip S. Wells, Jannick A. N. Dorresteijn, Mathilde Nijkeuter, VTE PREDICT study Grp
Summary: This study aimed to develop and validate models for predicting 5-year risks of recurrence and bleeding in VTE patients without cancer. The models were derived from patient data and validated externally, showing good agreement between predicted and observed risks for up to 5 years.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Mudassir Wani, Abdullah Al-Mitwalli, Subhabrata Mukherjee, Ghulam Nabi, Bhaskar K. Somani, Jayasimha Abbaraju, Sanjeev Madaan
Summary: The aim of this study was to investigate the occurrence and risk factors of venous thromboembolism (VTE) in post-radical prostatectomy patients. It was found that the overall incidence of VTE in post-RP patients is 1%, and minimally invasive procedures and RP without pelvic lymph node dissection are associated with a lower risk of developing VTE. Additional pharmacological prophylaxis may not be necessary in all cases and should be considered in high-risk patients only.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Beata Franczyk, Anna Gluba-Brzozka, Janusz Lawinski, Magdalena Rysz-Gorzynska, Jacek Rysz
Summary: VTE, consisting of DVT and PE, is a major cause of cardiovascular disease. Current diagnosis and treatment guidance for VTE are limited, and there is a lack of understanding of the mechanisms and pathways responsible for the occurrence of observed alterations. The application of metabolomics profiling may play a significant role in early diagnosis and management, but more research is needed to fully understand VTE-related metabolic changes.
Article
Oncology
Deanna Glassman, Nicholas W. Bateman, Sanghoon Lee, Li Zhao, Jun Yao, Yukun Tan, Cristina Ivan, Kelly M. Rangel, Jianhua Zhang, Kelly A. Conrads, Brian L. Hood, Tamara Abulez, P. Andrew Futreal, Nicole D. Fleming, Vahid Afshar-Kharghan, George L. Maxwell, Thomas P. Conrads, Ken Chen, Anil K. Sood
Summary: Ovarian cancer patients with venous thromboembolism (VTE) have molecular differences compared to those without. VTE is associated with upregulated inflammatory and coagulation pathways, and correlated with the expression of platelet-derived growth factor subunit B (PDGFB) and extracellular proteins, namely collagens.
Article
Medicine, General & Internal
Jean Philippe Galanaud, Jameel Abdulrehman, A. Lazo-Langner, Gregoire Le Gal, Sudeep Shivakumar, Sam Schulman, Susan Kahn
Summary: The study evaluates the efficacy of a venoactive drug in treating PTS and recruits 86 patients with PTS for the trial. The primary outcome is the proportion of patients with improvement in VS, with main secondary outcomes including quality of life and patient satisfaction.
Article
Cardiac & Cardiovascular Systems
Reo Hata, Yugo Yamashita, Takeshi Morimoto, Kazushige Kadota, Hidewo Amano, Ryosuke Murai, Kohei Osakada, Arata Sano, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Kosuke Doi, Yohei Kobayashi, Mamoru Toyofuku, Toshiaki Izumi, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Syunsuke Saga, Yuji Nishimoto, Tomoki Sasa, Jiro Sakamoto, Minako Kinoshita, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Yuta Tsujisaka, Yuta Seko, Kazuki Matsushita, Fumiya Yoneda, Takao Kato, Koh Ono, Takeshi Kimura
Summary: The study investigated the peri-procedural management and prognosis of patients with VTE who underwent invasive procedures during follow-up in a large multicenter VTE registry. The 30-day incidence rates of recurrent VTE and major bleeding events were 2.7% and 5.4%, respectively.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Review
Hematology
Gina Perrella, Magdolna Nagy, Steve P. Watson, Johan W. M. Heemskerk
Summary: GPVI is a receptor expressed on megakaryocytes and platelets that plays a role in both arterial and venous thrombus formation, as well as in the formation of platelet-leukocyte complexes. It is emerging as a potential therapeutic target for venous thrombosis, pulmonary thromboembolism, and cancer metastasis due to its involvement in venous thrombus formation and thromboinflammation. Circulating soluble GPVI is also being explored as a biomarker for thrombosis-related complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Steve Raoul Noumegni, Cecile Tromeur, Clement Hoffmann, Raphael Le Mao, Emmanuelle Le Moigne, Claire de Moreuil, Vincent Mansourati, Bahaa Nasr, Jean-Christophe Gentric, Marie Guegan, Elise Poulhazan, Luc Bressollette, Karine Lacut, Romain Didier, Francis Couturaud
Summary: Patients with first episodes of VTE are at increased risk of recurrent VTE and ATE during and after anticoagulation. Risk factors include age, cancer-associated VTE, and unprovoked VTE.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Oncology
Takaki Yoshikawa, Takeshi Sano, Masanori Terashima, Kensei Yamaguchi, Etsuro Bando, Ryohei Kawabata, Hiroshi Yabusaki, Hisashi Shinohara, Mari S. Oba, Tetsuya Kimura, Atsushi Takita, Mitsuru Sasako
Summary: This study is a large-scale, multicenter, prospective registry that aims to investigate the incidence and risk factors of venous thromboembolism (VTE) in adult Japanese patients with solid tumors. The analysis of stomach cancer patients revealed that female sex, age >= 65 years, VTE history, and D-dimer > 1.2 μg/mL were independent risk factors for VTE. Additionally, screening for D-dimer before starting cancer treatment is necessary, even for asymptomatic patients.
Article
Hematology
Alexander G. G. Turpie, Alfredo E. Farjat, Sylvia Haas, Walter Ageno, Jeffrey Weitz, Samuel Z. Goldhaber, Shinya Goto, Pantep Angchaisuksiri, Gloria Kayani, Renato D. Lopes, Chern-En Chiang, Harry Gibbs, Eric Tse, Peter Verhamme, Hugo ten Cate, Juan Muntaner, Sebastian Schellong, Henri Bounameaux, Paolo Prandoni, Uma Maheshwari, Ajay K. Kakkar
Summary: GARFIELD-VTE is an observational study that aims to collect clinical data of patients with deep vein thrombosis and pulmonary embolism worldwide. The study found that the highest accumulation of events occurred within the first 12 months after diagnosis, which may help identify treatment gaps and improve patient outcomes.
THROMBOSIS RESEARCH
(2023)
Article
Oncology
Maureen D. Moore, Christopher Agrusa, Timothy M. Ullmann, Toni Beninato, Rasa Zarnegar, Thomas J. Fahey, Brendan M. Finnerty
Summary: This study aimed to determine the incidence and risk factors of venous thromboembolism (VTE) after adrenalectomy for adrenal cortical carcinoma (ACC). The results showed that the occurrence of postoperative VTE was highest in ACC patients, with age, presence of adrenal cancer, and Khorana score being identified as risk factors. ACC patients with increased age and/or Khorana score >= 2 should be considered for extended prophylaxis.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Deborah Schrag, Hajime Uno, Rachel Rosovsky, Cynthia Rutherford, Kristen Sanfilippo, John L. Villano, Monic Drescher, Nagesh Jayaram, Chris Holmes, Lawrence Feldman, Ottavia Zattra, Haley Farrar-Muir, Christine Cronin, Ethan Basch, Anna Weiss, Jean M. Connors
Summary: DOACs were found to be noninferior to LMWH in preventing recurrent VTE in patients with cancer over a 6-month follow-up period. These findings support the use of DOACs as a preventive measure in this patient population.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Deborah Schrag, Hajime Uno, Rachel Rosovsky, Cynthia Rutherford, Kristen Sanfilippo, John L. Villano, Monic Drescher, Nagesh Jayaram, Chris Holmes, Lawrence Feldman, Ottavia Zattra, Haley Farrar-Muir, Christine Cronin, Ethan Basch, Anna Weiss, Jean M. Connors
Summary: The effectiveness of direct oral anticoagulants (DOACs) compared to low-molecular-weight heparin (LMWH) for preventing recurrent venous thromboembolism (VTE) in cancer patients is uncertain. This study found that DOACs were noninferior to LMWH in preventing recurrent VTE in cancer patients, with similar rates of bleeding.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kotaro Takahashi, Yugo Yamashita, Takeshi Morimoto, Tomohisa Tada, Hiroki Sakamoto, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Yuji Nishimoto, Jiro Sakamoto, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Takao Kato, Koh Ono, Takeshi Kimura
Summary: This study investigates the long-term clinical outcomes of patients with venous thromboembolism (VTE) in relation to age. The findings suggest that older patients have a lower risk of recurrent VTE compared to younger patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Hematology
John W. Eikelboom, Jeffrey I. Weitz
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Cardiac & Cardiovascular Systems
Nick van Es, Raffaele De Caterina, Jeffrey Weitz
Summary: In the past 20 years, there has been a transition from vitamin K antagonists to direct oral anticoagulants (DOACs). DOACs include dabigatran, apixaban, edoxaban, and rivaroxaban. Although DOACs are associated with less serious bleeding, reversal agents may be needed in cases of serious bleeding or urgent surgery/intervention. This paper provides insight into reversing the effects of DOACs, discusses new reversal agents, and outlines a strategic framework for reversing factor XI inhibitors in clinical trials.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Meichan Zhu, Lisa van Stiphout, Mustafa Karabulut, Angelica Perez Fornos, Nils Guinand, Kenneth Meijer, Raymond van de Berg, Christopher McCrum
Summary: Bilateral vestibulopathy (BVP) causes unsteadiness in walking, especially in darkness or on uneven ground, leading to falls. The study found that the Mini-BESTest is feasible in BVP, with participants scoring significantly lower than healthy participants. The negative correlation between age and balance is more significant in BVP.
JOURNAL OF NEUROLOGY
(2023)
Article
Hematology
Katherine J. Kearney, Henri M. H. Spronk, Jonas Emsley, Nigel S. Key, Helen Philippou
Summary: It was previously believed that plasma kallikrein (PKa) only functioned to activate factor XII (FXII) in the coagulation cascade. However, recent studies have revealed a new pathway where PKa can directly activate factor IX (FIX). These studies identified the binding of FIX/FIXa with PK/PKa, the PKa-induced thrombin generation and clot formation independent of FXI, and the increased formation of FIXa:AT complexes due to PKa activity. The existence of both a canonical (FXIa-dependent) and non-canonical (PKa-dependent) pathway of FIX activation is suggested.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Rida A. Malik, Peng Liao, Ji Zhou, Rawaa Hussain, James C. Fredenburgh, Lisa Hettrick, Alexey S. Revenko, Jeffrey I. Weitz
Summary: FXII knockdown prolongs catheter occlusion time, while HRG knockdown shortens it. HRG supplementation may prevent catheter thrombosis.
Article
Multidisciplinary Sciences
Rachel Senden, Rik Marcellis, Kenneth Meijer, Paul Willems, Ton Lenssen, Heleen Staal, Yvonne Janssen, Vincent Groen, Roland Jeroen Vermeulen, Marianne Witlox
Summary: In this article, gait data of typically developing children walking at different speeds is shared. The raw and processed data, including data of each single step, as well as the demographics and physical examination results of the subjects, are presented. The gait data is also presented per age group, providing insight into the normal gait pattern of TD children of different ages. Gait analysis was performed using a virtual environment, and the data was processed using Matlab algorithms.
Review
Hematology
Noel C. Chan, Jeffrey I. Weitz
Summary: This review discusses the role of FXI and FXII in the pathogenesis of venous thromboembolism, explains why FXI is a better target, and describes the potential advantages of FXI inhibitors over currently available anticoagulants. It also provides an overview of the FXI inhibitors under development and their potential in addressing unmet needs in venous thromboembolism management.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Samuel K. Lee, Rida A. Malik, Ji Zhou, Wei Wang, Peter L. Gross, Jeffrey I. Weitz, Rithwik Ramachandran, Bernardo L. Trigatti
Summary: This study investigated the effects of PAR4 inhibitory pepducin (RAG8) on coronary artery disease in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet. The results showed that RAG8 reduced coronary artery atherosclerosis and myocardial fibrosis, as well as platelet and leukocyte accumulation in atherosclerotic coronary arteries.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Irene Moll, Rik G. J. Marcellis, Sabine M. Fleuren, Marcel L. P. Coenen, Rachel H. J. Senden, Paul J. B. Willems, Lucianne A. W. M. Speth, M. Adhiambo Witlox, Kenneth Meijer, R. Jeroen Vermeulen
Summary: This study suggests that FES may be as effective as traditional treatment for individuals with unilateral spastic CP, but patient selection and thorough testing and follow-up are crucial.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Neurosciences
Bas Van Hooren, Steven M. Hirsch, Kenneth Meijer
Summary: This study assessed different methods for normalizing joint moments during running. The findings suggest that scaling by mass, mass*height, and mass*leg length can satisfy the assumptions and provide relatively good results.
Review
Hematology
James C. Fredenburgh, Jeffrey I. Weitz
Summary: Oral anticoagulants are widely used for preventing and treating thrombosis. Direct oral anticoagulants (DOACs) such as dabigatran and apixaban have replaced traditional anticoagulants. New DOACs like asundexian and milvexian, targeting FXIa, offer potential advantages over existing ones.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Endocrinology & Metabolism
M. R. Schene, K. Meijer, D. Cheung, H. C. Willems, J. H. M. Driessen, L. Vranken, J. P. van den Bergh, C. E. Wyers
Summary: Physical capacity (PC) and physical activity (PA) are used to categorize physical performance in the can do, do do framework. This study examined the physical performance of patients attending the fracture liaison service (FLS). It was found that approximately 20% of the patients were unable to perform certain physical activities but still engaged in them, and they had a higher prevalence of fall and fracture risk factors compared to those who could perform the activities.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Hematology
Ruiqi Yin, Vishal Patel, Rida A. Malik, James C. Fredenburgh, Jeffrey I. Weitz
Summary: Polyphosphate (polyP) serves as a template to promote feedback activation of factor XI by thrombin. This study determines the contribution of thrombin exosites 1 and 2 to polyP-induced potentiation of FXI activation. The results show that polyP accelerates FXI activation by thrombin and exosite 2 ligands attenuate this activation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Zeyu Guan, Roxanna Wang, Rawaa H. Hussain, James C. Fredenburgh, Iqbal H. Jaffer, Jeffrey I. Weitz
Summary: This study compared the effects of apixaban, rivaroxaban, and enoxaparin on the prevention of catheter-induced clotting in vitro. The results showed that apixaban and rivaroxaban were significantly less potent than enoxaparin in preventing catheter-induced clotting and thrombin generation. Clinical trials are needed to compare the efficacy of low-molecular-weight heparin with that of direct oral anticoagulants for both prevention and treatment of catheter thrombosis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
John W. Eikelboom, Jeffrey I. Weitz
Summary: Although DOACs are preferred over VKAs for stroke prevention in most patients with AF, they are not recommended for those with rheumatic heart disease or mechanical heart valves. Results from the INVICTUS and PROACT Xa trials support the use of VKAs for these specific indications. This paper reviews the findings from these trials, provides insights into why VKAs were superior to DOACs, and discusses future directions for anticoagulation in these disorders.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
