4.8 Article

Four-component benzyne coupling reactions: A concise total synthesis of dehydroaltenuene B

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ORGANIC LETTERS
卷 10, 期 17, 页码 3833-3835

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AMER CHEMICAL SOC
DOI: 10.1021/ol8015435

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  1. Wolfson Foundation
  2. Engineering and Physical Sciences Research Council (UK)
  3. Commonwealth Scientific and Industrial Research Organization (Melbourne, Australia)

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A four-component coupling reaction of 3,5-dimethoxybenzyne with 2-methyl-2-cyclohexenylmagnesium chloride, carbon dioxide, and iodine was utilized as a key step in the first total synthesis of dehydroaltenuene B.

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