Article
Chemistry, Multidisciplinary
Veronica Egas Ortuno, Sunil Pulletikurti, Kollery S. Veena, Ramanarayanan Krishnamurthy
Summary: This study presents a robust synthesis method for cyclic phosphatidic acids (cPAs) and investigates their hydrolytic properties, which could advance the understanding of their biological properties and potential use as components of synthetic cells.
CHEMICAL COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
D. Roselyn Cerutis, Michael D. Weston, Takanari Miyamoto
Summary: Oral health is important for overall health, and periodontal disease (PDD) is a chronic inflammatory disease. Our research on lysophosphatidic acid (LPA) and its receptors (LPARs) in the oral system has implications for understanding cancer and immune responses. Further exploration of LPA's potential for controlling complex immune responses and signaling in the cellular microenvironment is needed to improve treatment for diseases like PDD, cancer, and emerging diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Agatha M. Reigoto, Sarah A. Andrade, Marianna C. R. R. Seixas, Manoel L. Costa, Claudia Mermelstein
Summary: Microscopy plays a crucial role in visualizing and studying the structure and function of cells in biomedical research. The usage of different microscopy techniques varies significantly between fields such as pharmacology and cell biology. While nearly half of articles in pharmacology journals did not utilize any microscopy method, almost all articles in cell biology journals incorporated microscopy. The most common microscopy methods across all fields were bright field and fluorescence (conventional and confocal).
Article
Neurosciences
Maria Puigdomenech-Poch, Anna Martinez-Muriana, Pol Andres-Benito, Isidre Ferrer, Jerold Chun, Ruben Lopez-Vales
Summary: Lysophosphatidic acid (LPA) and its G protein-coupled receptor LP(2) play important roles in the pathophysiology of ALS, with their genetic deletion showing protective effects in the early stages of the disease but shortening survival.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Chemistry, Organic
Jean-Baptiste Garsi, Solene Guggari, Thomas Deis, Myles Ma, Sofiane Hocine, Stephen Hanessian
Summary: This study presents a versatile synthetic approach for the production of C-3 disubstituted 2-oxa-5-azabicyclo[2.2.1]heptanes as carbon-atom bridged morpholines. Starting with 4R-hydroxy-L-proline, an acetic acid moiety is attached to the C-3 carbon of the 2-oxa-5-azabicyclo[2.2.1]heptane core, resulting in a framework similar to gamma-amino butyric acid (GABA). Further variations of the substituent on the tertiary C-3 atom lead to backbone-constrained analogues of FDA-approved drugs baclofen and pregabalin.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
C. Ruzza, M. Argentieri, F. Ferrari, E. Armani, M. Trevisani, G. Marchini, G. Calo'
Summary: Lysophosphatidic acid (LPA) is a bioactive phospholipid that modulates various biological functions through acting on LPA receptors. Overactivation of the LPA-LPA receptor system is implicated in several pathologies, making the identification and characterization of new LPA receptor ligands important. The use of label-free dynamic mass redistribution (DMR) assay has shown potential in characterizing LPA receptor ligands, leading to the discovery of a new LPA(1) inverse agonist.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Kaire Ojasalu, Sonja Lieber, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Imke Bullwinkel, Florian Finkernagel, Silke Reinartz, Sabine Mueller-Bruesselbach, Robert Grosse, Johannes Graumann, Rolf Mueller
Summary: Lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high-grade serous cancer (HGSC) and are associated with short relapse-free survival. LPA supports metastatic spread of cancer cells by activating multiple signaling pathways. However, a systematic analysis of the LPA-regulated signal transduction network in ovarian cancer cells has not been reported.
Article
Biochemistry & Molecular Biology
Jui-Chung Chiang, Wei-Min Chen, Kuan-Hung Lin, Kai Hsia, Ya-Hsuan Ho, Yueh-Chien Lin, Tang-Long Shen, Jen-Her Lu, Shih-Kuo Chen, Chao-Ling Yao, Benjamin P. C. Chen, Hsinyu Lee
Summary: This study reveals that lysophosphatidic acid (LPA) has opposing regulatory effects on erythrocyte differentiation through activation of LPA receptors 2 and 3. The expression of LPA(2) and LPA(3) in murine myeloid cells may determine the direction of myeloid differentiation, with LPA(2) inhibiting early myeloid differentiation and LPA(3) promoting erythrocyte production. Activation of LPA(3) is essential for the restoration of acute hemolytic anemia and correlates with erythropoiesis impairment in a premature aging model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Cell Biology
Chia-Lang Hsu, Chieh-Fan Yin, Yi-Wen Chang, Ya-Chih Fan, Shih-Han Lin, Yu-Ching Wu, Hsuan-Cheng Huang, Hsueh-Fen Juan
Summary: SNHG1 is an oncogenic long non-coding RNA that is aberrantly expressed in different tumor types. It plays a crucial role in maintaining the identity of neuroblastoma (NB) through chromatin regulation and interacts with core regulatory circuitry transcription factors.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Inorganic & Nuclear
Lu Fang, Siyang Yan, Huifang Wu, Mingrui Wang, Teng Du, Tianlong Wang, Jiaxu Liu, Changgong Meng, Xinwen Guo, Limin Ren
Summary: A defect-guided etching-regrowth strategy is proposed to selectively anchor active centers on the external surface for forming highly exposed acid sites in zeolite catalyst synthesis. The results show the prominent advantages of the hierarchical structure with highly exposed and synergetic acid sites.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Aamir Ali Shaikh, Alfatih Alamin, Chenxi Jia, Wei Gong, Xianjun Deng, Qingwen Shen, Yueyun Hong
Summary: Phosphatidic acid (PA) is a key signal molecule involved in osmotic stress responses in plants. LPAT2-derived PA plays a crucial role in salt and drought stress tolerance in rice by mediating ABA response and regulating ion homeostasis and protein kinase signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kuan-Hung Lin, Jui-Chung Chiang, Wei-Min Chen, Ya-Hsuan Ho, Chao-Ling Yao, Hsinyu Lee
Summary: The balance between LPA receptor subtypes, regulated by GATA factors, plays a critical role in lineage commitment of myeloid progenitors. Manipulation of GATA factors affects the expression levels of LPA(2) and LPA3, indicating a novel mechanism regulating erythropoiesis and megakaryopoiesis. The physical interaction between GATA factors and the promoter region of LPAR genes further supports this regulatory role.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Foteini Dimakopoulou, Constantinos G. Efthymiou, Andreas Kourtellaris, Ciaran O'Malley, Lamis Alaa Eldin Refat, Anastasios Tasiopoulos, Patrick Mcardle, Constantina Papatriantafyllopoulou
Summary: The study focuses on the isolation of mixed-ligand compounds and their potential applications. The combination of 2-pyridyl oximes or 2-pyridyl alcohols with 2-hydroxyterephthalic acid and 2,5-dihydroxyterephthalic acid has resulted in the synthesis of 1D coordination polymers and a metal cluster. Compound 4 exhibits a high capacity for Co2+ uptake due to the presence of free coordination sites.
Article
Biochemistry & Molecular Biology
Bo Young Jeong, Kyung Hwa Cho, Se-Hee Yoon, Chang Gyo Park, Hwan-Woo Park, Hoi Young Lee
Summary: LPA induces DDR2 expression through the activation of the PI3K/Akt/mTOR/HIF-1α/Twist1 signaling axes, aggravating ovarian cancer cell invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Organic
Radhika Anand, Pankaj Singh Cham, Veeranjaneyulu Gannedi, Sumit Sharma, Mukesh Kumar, Rohit Singh, Ram A. Vishwakarma, Parvinder Pal Singh
Summary: Here, we report a concise and stereoselective synthesis route to (-)-cannabidiol (-CBD) from readily available starting material R-(+)-limonene. The synthesis involved selective functionalization of limonene and subsequent coupling reaction to generate key chiral intermediates, leading to the synthesis of regiospecific (-)-CBD. The method was also successfully applied to the synthesis of analogues. Additionally, the opposite isomer (+)-cannabidiol was synthesized from S-(-)-limonene.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
