Article
Medicine, General & Internal
Enrico Peira, Francesco Sensi, Luca Rei, Ruben Gianeri, Domenico Tortora, Francesco Fiz, Arnoldo Piccardo, Gianluca Bottoni, Giovanni Morana, Andrea Chincarini
Summary: This study aims to evaluate the use of a computer-aided approach to calculate the tumor-to-background ratio in pediatric-type diffuse gliomas (PDGs) using [F-18]F-DOPA positron emission tomography (PET). The results showed that the computer-aided approach yielded similar diagnostic and prognostic information compared to the manual procedure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zhong-Hui Shen, Si-Yuan Lu, Jing-Yun Zheng, Xiang-Zhi Zhang, Jin-Bao Peng, Ai-Jun Ma
Summary: Bioassay-guided isolation of spiroaspertrione A from Aspergillus sp. TJ23 cultures in 2017 demonstrated its potent resensitization of methicillin-resistant Staphylococcus aureus to oxacillin. This study also revealed a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate to construct the unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system.
FRONTIERS IN CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Julien Robert-Paganin, Xiao-Ping Xu, Mark F. Swift, Daniel Auguin, James P. Robblee, Hailong Lu, Patricia M. Fagnant, Elena B. Krementsova, Kathleen M. Trybus, Anne Houdusse, Niels Volkmann, Dorit Hanein
Summary: This study presents the atomic structure of the Plasmodium falciparum actomyosin system and reveals the detailed interactions required for producing the force and motion during infectivity. Despite significant differences in the myosin and actin elements, the footprint of the myosin motor on filamentous actin remains conserved compared to higher eukaryotes.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhikai Chen, Xiaoli Jiang, Yagang Zhang, Wei Li, Zhiqiang Tang, Yanxia Liu, Lin Zhao
Summary: Biochar is a promising candidate for sustainable energy systems and environmental technology applications, but improving its mechanical properties remains a challenge. In this study, a generic strategy to enhance the mechanical properties of bio-based carbon materials through inorganic skeleton reinforcement is proposed. Silane, geopolymer, and inorganic gel are used as precursors, and the composites are characterized. Two types of inorganic skeleton reinforcement mechanisms are employed to improve the mechanical properties. The prepared carbon materials show a significant improvement in mechanical strength and excellent adsorption performance for methylene blue dye.
Article
Chemistry, Organic
Wenjie Zhang, Jiahui Bu, Lei Wang, Pinhua Li, Hongji Li
Summary: A sunlight-mediated [3 + 2] cycloaddition reaction between azobenzenes and aryne precursors generated from ortho-(trimethylsilyl)phenyl triflates has been successfully developed, offering an efficient method for the construction of the carbazole backbone without the need for transition metals or photocatalysts.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Liliana Oniciuc, Dorina Amariucai-Mantu, Dumitrela Diaconu, Violeta Mangalagiu, Ramona Danac, Vasilichia Antoci, Ionel I. Mangalagiu
Summary: This study presents the synthesis, structural characterization, and in vitro evaluation of newly benzo[f]quinoline derivatives as potential anticancer agents. The synthesis process involves quaternization and dipolar cycloaddition reaction, and the compounds were characterized by FTIR, NMR, and X-ray diffraction. The most active compounds were quaternary salts 3d and 3f, with salt 3d showing non-selective activity against various types of cancer cells and salt 3f exhibiting highly selective activity against leukemia cells. Compound 3d also demonstrated remarkable cytotoxic efficiency against four different types of cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Information Systems
Ali Raza, Azam Mehmood Qadri, Iqra Akhtar, Nagwan Abdel Samee, Maali Alabdulhafith
Summary: Human pose and gesture estimation play a crucial role in correcting physiotherapy fitness exercises. This research proposes an efficient artificial intelligence method for human pose estimation during physiotherapy fitness exercises. The experiments demonstrate the high performance of the proposed method and its potential to assist specialists in injury prevention and optimizing exercise outcomes. Furthermore, this study enhances the capabilities of remote monitoring and guidance for physiotherapists.
Article
Business
Jiho Lee, Namuk Ko, Janghyeok Yoon, Changho Son
Summary: This study presents a TOD model based on F-terms, utilizing a link prediction analysis to identify technology opportunities using F-term networks and firm technology portfolios. Through four steps, the model can assist firms in discovering high-practicality technology opportunities.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2021)
Article
Mechanics
L. A. T. Mororo, A. Poot, F. P. van der Meer
Summary: This paper introduces a generalized framework for the Thick Level Set method (TLSV2) and addresses two major issues with the method. The TLSV2 combines continuum damage modeling and discrete cohesive crack modeling to handle different types of cracks and allow for stiffness recovery upon contact.
ENGINEERING FRACTURE MECHANICS
(2022)
Article
Materials Science, Multidisciplinary
Yu Zhang, Wei Guo, Qiang Jia, Baoliang Zhang, Ying Zhu, Hongqiang Zhang
Summary: SiCf/SiC composites can improve the operating temperature and thrust-weight ratio of aero-engines, and their effective joining with superalloys can solve the problem of poor machinability. In this study, graphene-reinforced Cu (G-Cu) foam was introduced as an energy-absorbing interlayer to relieve the residual stress in the brazed joint. The G-Cu foam played a protective role, and its foam structure remained intact, leading to good microstructure and improved performance.
MATERIALS CHARACTERIZATION
(2023)
Article
Environmental Sciences
Sheng Xu, Xin Li, Jiayan Yun, Shanshan Xu
Summary: This paper proposes a four-step framework for tree skeleton extraction, achieving complete skeletons through optimizing paths and interpolating points, and providing an efficient solution for tree skeleton and structure study.
Article
Chemistry, Physical
Bruno Nunes Cabral Tenorio, Piero Decleva, Sonia Coriani
Summary: In this study, the Double Core-Hole (DCH) states of small molecules were assessed using advanced theoretical methods, with accurate results that are in excellent agreement with experimental data. The K-2 shake-up spectra of H2O and C2H2n molecules were fully characterized for the first time.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ningning Li, Siyi Chen, Kui Xu, Meng -Ting He, Meng-Qiu Dong, Qiangfeng Cliff Zhang, Ning Gao
Summary: The spectrin-based membrane skeleton is a crucial component of metazoan cells, and mutations in its proteins can lead to various human diseases. This study presents the cryo-EM structures of the spectrin-actin junctional complex, revealing its organization and interactions. The findings provide a structural basis for understanding the assembly and dynamics of the membrane skeleton and shed light on the mechanisms of F-actin-binding factors in other systems.
Article
Astronomy & Astrophysics
Atsushi Taruya, Shohei Saga
Summary: In this paper, the dependence of the soliton core properties on the halo characteristics in the fuzzy dark matter model is analytically studied. The key expression for the soliton core radius is derived based on the ground-state eigenfunction, and the core-halo mass relations are found to be related to the concentration-halo mass relation.
Article
Chemistry, Multidisciplinary
Tomohiro Kurose, Moeko Itoga, Takeshi Nanjo, Yoshiji Takemoto, Chihiro Tsukano
Summary: In this study, we successfully synthesized the core structure of Lyconesidine B and achieved stereoselective derivatization using different synthetic strategies. The synthesis of the tetracyclic core structure was achieved through cyclopropanation and ene-yne metathesis, while the asymmetric cyclopropanation introduced the initial chiral center.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Chemistry, Multidisciplinary
Zhiqiang Ma, Xiao Wang, Yuyong Ma, Chuo Chen
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Chemistry, Organic
Zhiqiang Ma, Lin You, Chuo Chen
JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Zhiqiang Ma, Chuo Chen
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2018)
Article
Multidisciplinary Sciences
Hua Wang, Shuiqing Hu, Xiang Chen, Heping Shi, Chuo Chen, Lijun Sun, Zhijian J. Chen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Chemistry, Organic
Lei Han, Ji-Bao Xia, Lin You, Chuo Chen
Article
Chemistry, Organic
Lin You, Chuo Chen
Article
Multidisciplinary Sciences
C-W. Fan, N. Yarravarapu, H. Shi, O. Kulak, J. Kim, C. Chen, L. Lum
SCIENTIFIC REPORTS
(2018)
Article
Medicine, General & Internal
Li-shu Zhang, Xunlei Kang, Jianming Lu, Yuannyu Zhang, Xiaofeng Wu, Guojin Wu, Junke Zheng, Rubina Tuladhar, Heping Shi, Qiaoling Wang, Lorraine Morlock, Huiyu Yao, Lily Jun-shen Huang, Pascal Maire, James Kim, Noelle Williams, Jian Xu, Chuo Chen, Cheng Cheng Zhang, Lawrence Lum
Article
Biochemistry & Molecular Biology
Rubina Tuladhar, Nageswari Yarravarapu, Yuyong Ma, Chengwei Zhang, Jeremiah Herbert, James Kim, Chuo Chen, Lawrence Lum
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Shuai Wang, Lei Han, Jungsoo Han, Peng Li, Qing Ding, Qing-Jun Zhang, Zhi-Ping Liu, Chuo Chen, Yonghao Yu
NATURE CHEMICAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Andrea N. Johnston, Yuyong Ma, Hua Liu, Shuzhen Liu, Sarah Hanna-Addams, She Chen, Chuo Chen, Zhigao Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Yaqin Deng, Lin You, Yong Lu, Sungwon Han, Jingcheng Wang, Nikitha Vicas, Chuo Chen, Jin Ye
Summary: Ceramide regulates physiological and pathological reactions by inverting the topology of certain transmembrane proteins, but how cells sense ceramide levels to trigger regulated alternative translocation remains unclear.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
You-Tong Wu, Yan Fang, Qi Wei, Heping Shi, Huiling Tan, Yafang Deng, Zhiqun Zeng, Jian Qiu, Chuo Chen, Lijun Sun, Zhijian J. Chen
Summary: The study demonstrates the development of antibody-drug conjugates (ADCs) by conjugating a STING agonist to tumor-targeting antibodies, which showed well-tolerated systemic administration and potent antitumor efficacy. The STING ADC also promoted multiple aspects of antitumor immune responses, highlighting its potential for clinical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Yong Lu, Lin You, Chuo Chen
Summary: Technologies for detecting and conjugating cysteine disulfide are crucial for studying protein functions and developing therapeutic agents. The current method of disulfide modification requires reductive cleavage, which makes it difficult to distinguish disulfides from free thiols. This study presents a new method called Redox-assisted Disulfide Direct Conjugation (RDDC) that enables disulfide rebridging without interfering with free thiols.
CHEMICAL COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Chiho Kim, Chuo Chen, Yonghao Yu
Summary: PARP1 plays a critical role in regulating DNA damage response and is sensitive to PARP1 inhibitors in cancers with homologous recombination deficiency. Aberrant activation of PARP1 in non-oncological diseases can lead to cell death, and while PARP1 deletion offers protection in animal models, current PARP1 inhibitors may induce PARP1 trapping, causing DNA damage and cytotoxicity. Research on PARP1 PROTAC compounds for potential use in non-oncological diseases is ongoing.
CELL CHEMICAL BIOLOGY
(2021)
